Clinical trial · Observational
Conservative Management in Patients Diagnosed With Grade 2 or Grade 3 CIN
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Consecutive inclusion and collection of information for all women attending the Cervical Disease Unit with an histological diagnosis of grade 2 or grade 3 CIN during the last 5 years, from January 2012 to December 2016, which meet the inclusion criteria, have voluntarily manifested pregnancy intendedness and had a minimum follow-up time of 2 years and a maximum of 7. The aim is to evaluate whether the HSIL resolution rates (CIN 2 or CIN 3) are sufficient to support conservative management.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Disease Progression | — | UNRESOLVED | — |
| High-Grade Squamous Intraepithelial Lesions | — | UNRESOLVED | — |
| Neoplasm Regression, Spontaneous | — | UNRESOLVED | — |
| Papillomavirus Infections | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (2)
- measure
- H-SIL Resolution
- timeFrame
- 24 months
- description
- In cases where H-SIL (cytologic, histological and colposcopic) is no longer detected during follow-up. Include the strict resolution, indulgent resolution and regression
- measure
- H-SIL Regression
- timeFrame
- 24 months
- description
- H-SIL is not detected, but with a low grade cytological, histologic or colposcopic lesion
Secondary outcomes (4)
- measure
- Factors probably related to the resolution
- timeFrame
- 24 months
- description
- Demographics (age and origin), viral type, cytology, biopsy and colposcopy will be recorded at the beginning and end of the follow-up, as well as time until resolution, regression or progression and conization result.
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 50 Years
Show eligibility criteria text
Inclusion Criteria: * Reproductive age and willing to get pregnant in the future * Acceptance of conservative management * Commitment to study visits. * Colposcopy with zone of transformation (ZT) type 1 or 2 (Unio esco-columnar totally visible) with image compatible with H-SIL and visible in its entirety. Exclusion Criteria: * Pregnant women * Immunosuppression for human immunodeficiency virus (HIV) or iatrogenic type * suspicion or diagnosis of Glandular Cell Atipia (ACG), Adenocarcinoma in situ (AIS) or cervical cancer (CC) * Provided that inclusion criteria are not met
References
Publications (0)
Data not yet available