Clinical trial · Interventional
Quantitative Fluorescent Guided Robotic Surgery for Cancer of the Gastroesophageal Junction
NCT04107623CI-TRIAL-00054613completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The investigators also aim to use our previously described quantifying method (q-ICG), to evaluate changes in gastric perfusion, during resection of cancer in the gastroesophageal junction (GEJ) and if a change in the operative technique influences microvascular flow in the gastroesophageal (GE) anastomosis.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Stomach Neoplasms | Gastric Neoplasm | ALIAS | 0.90 |
| Surgery | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Indocyanine Green | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Grupp 1
- description
- Patients will be allocated to preserving the right gastric artery during the resection of GEJ cancer.
- interventionNames
- Diagnostic Test: Indocyanine Green
- type
- ACTIVE_COMPARATOR
- label
- Grupp 2
- description
- Patients will be allocated to an extensive lymphatic resection (ligating the right gastric artery) during the resection of GEJ cancer.
- interventionNames
- Diagnostic Test: Indocyanine Green
Primary outcomes (1)
- measure
- perfusion assessment
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients (above 18 years) scheduled for planned open or robot-assisted resection of gastroesophageal junction cancer. Exclusion Criteria: * Allergy towards; iodine, indocyanine green or shellfish * Severe liver insufficiency * Thyrotoxicosis * Nephropathy requiring dialysis * Pregnancy or lactation * Legally incompetent for any reason * Withdrawal of inclusion consent at any time
References
Publications (60)
- BACKGROUNDChiappa A, Andreoni B, Dionigi R, Spaggiari L, Foschi D, Polvani G, Orecchia R, Fazio N, Pravettoni G, Cossu ML, Galetta D, Venturino M, Ferrari C, Macone L, Crosta C, Bonanni B, Biffi R. A rationale multidisciplinary approach for treatment of esophageal and gastroesophageal junction cancer: Accurate review of management and perspectives. Crit Rev Oncol Hematol. 2018 Dec;132:161-168. doi: 10.1016/j.critrevonc.2018.10.002. Epub 2018 Oct 13. PMID 30447922
- BACKGROUNDKofoed SC, Calatayud D, Jensen LS, Helgstrand F, Achiam MP, De Heer P, Svendsen LB; Danish Esophageal, Cardia and Stomach Cancer Group. Intrathoracic anastomotic leakage after gastroesophageal cancer resection is associated with increased risk of recurrence. J Thorac Cardiovasc Surg. 2015 Jul;150(1):42-8. doi: 10.1016/j.jtcvs.2015.04.030. Epub 2015 Apr 21. PMID 25986493
- BACKGROUNDAkiyama H, Miyazono H, Tsurumaru M, Hashimoto C, Kawamura T. Use of the stomach as an esophageal substitute. Ann Surg. 1978 Nov;188(5):606-10. doi: 10.1097/00000658-197811000-00004. PMID 718285
- BACKGROUNDNdoye JM, Dia A, Ndiaye A, Fall B, Diop M, Ndiaye A, Sow ML. Arteriography of three models of gastric oesophagoplasty: the whole stomach, a wide gastric tube and a narrow gastric tube. Surg Radiol Anat. 2006 Oct;28(5):429-37. doi: 10.1007/s00276-006-0129-5. Epub 2006 Jul 19. PMID 16850349
- BACKGROUNDCollard JM, Tinton N, Malaise J, Romagnoli R, Otte JB, Kestens PJ. Esophageal replacement: gastric tube or whole stomach? Ann Thorac Surg. 1995 Aug;60(2):261-6; discussion 267. doi: 10.1016/0003-4975(95)00411-d. PMID 7646084
- BACKGROUNDNussbaum DP, Pappas TN, Perez A. Laparoscopic Total Gastrectomy in the Western Patient Population: Tips, Techniques, and Evidence-based Practice. Surg Laparosc Endosc Percutan Tech. 2015 Dec;25(6):455-61. doi: 10.1097/SLE.0000000000000210. PMID 26492457