Clinical trial · Interventional
ARAPS Study on Accelerated Liver Regeneration
ARAPS Study: Comparison of Portal Vein Embolization With Radiofrequency Ablation Versus Portal Vein Embolization Alone for Accelerated Liver Regeneration: A Randomized Controlled Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Liver resection is the golden standard in the treatment of hepatic malignancies. The size and function of the remnant liver is a major concern. If the future liver remnant (FLR) is below 30 % of the initial liver volume, the risk of post hepatectomy liver insufficiency rises. Several techniques have been developed to increase the size of FLR before liver resection. In this study a new technique ARAPS (portal vein embolization with radio frequency ablation) is compared to portal vein embolization alone for accelerated liver growth in the FLR. This is done in a randomized controlled trial.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Liver Cancer | Malignant Liver Neoplasm | CURATED_EXACT | 0.92 |
| Liver Failure | — | UNRESOLVED | — |
| Liver Metastases | — | UNRESOLVED | — |
| Liver Regeneration | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| ARAPS | Procedure | — | UNRESOLVED |
| PVE | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- OTHER
- label
- PVE (Portal vein embolisation)
- description
- Standard of care when FLR is small.
- interventionNames
- Procedure: PVE
- type
- EXPERIMENTAL
- label
- ARAPS (Portal vein embolisation and associating RFA)
- description
- Experimental arm with PVE combined with RFA to induce accelerated liver hypertrophy.
- interventionNames
- Procedure: ARAPS
Primary outcomes (4)
- measure
- Liver volume
- timeFrame
- 7 days
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Patients with Colorectal liver metastasis; initially considered unresectable or borderline resectable due to an expected postoperative FLR volume of \<30 % 2. Extrahepatic metastatic disease is not an exclusion criteria if it can be treated with curative intent Exclusion Criteria: 1. Liver cirrhosis 2. Significant comorbidity rendering subjects unsuitable for major surgery
References
Publications (0)
Data not yet available