Trial Comparing Parenteral Nutrition (PN) Using Eurotubes® vs. 2/3-chamber Bags in Subjects With Solid Tumors Requiring PN (PEKANNUSS)

Inclusion Criteria:

1. Age ≥ 18 years
2. Histologically confirmed metastatic or localized solid tumor. Perioperative setting of HPN is allowed if HPN is planned for a duration of ≥ 2 months
3. ECOG performance status of 0, 1, 2 or 3
4. Indication for PN (the subject needs a PN independent of the trial)
5. PN planned for 3 or more days per week
6. Negative pregnancy test in women of childbearing potential
7. Willingness to perform double-barrier contraception during study for women of childbearing potential
8. Willingness to maintain a study diary
9. Life expectancy \> 3 months
10. Written informed consent

Exclusion Criteria:

1. \> 4 weeks of consecutive (3 ≥ days per week) parenteral nutrition in the last 3 months prior to study enrolment
2. Participation in another interventional clinical trial that could influence the endpoints of this trial or planned participation in such a study at the same time as this study is active (participation in other trials is possible in the follow up time for OS). The study is active, if the patients receive study treatment (PN), did not discontinue the trial for other reasons, and is still within the 12 months active study period
3. Current catheter related infection at baseline
4. Pregnancy or breastfeeding
5. Known hypertriglyceridemia ≥ CTCAE grade 3
6. Unable or unwilling to provide written informed consent and to comply with the study protocol
7. Uncontrolled diabetes mellitus
8. Congestive heart failure NYHA ≥ 3
9. Renal insufficiency GFR \< 30 ml/min
10. Uncontrolled infection
11. Liver insufficiency