Clinical trial · Observational
Optimisation of Radiotherapy in Rectal Cancer (ORREC)
Optimisation of Radiotherapy to Achieve Increased Organ Preservation in Rectal Cancer (ORREC)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a retrospective study using images acquired routinely for diagnosis of rectal cancer to see if these could be used to predict responses to radiotherapy treatment and if it can, whether the treatment can be optimised to produce better outcome for patients. Using a clinical database, patients who have had neo-adjuvant chemo-radiotherapy will be recruited, their diagnostic images and radiotherapy planning scan will be obtained. By use of imaging registration and clinical information, the question of why some patients respond well to radiotherapy and some don't could be answered.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Rectal Adenocarcinoma | Rectal Adenocarcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| chemo-radiotherapy | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (3)
- measure
- Radiotherapy volumes (cm^3)
- timeFrame
- 24 months
- description
- The volume that receives radiotherapy treatment.
- measure
- Radiotherapy dose distribution (Gy/cm^3)
- timeFrame
- 24 months
- description
- Radiotherapy dose delivered to a given volume
- measure
- MR radiomics extracted features.
- timeFrame
- 24 months
- description
- Distinctive qualitative pixel features that can be extracted from area of disease in radiological images.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Histologically confirmed rectal adenocarcinoma. * Received pelvic radiotherapy (+/- chemotherapy) as neo-adjuvant treatment * Age 18 and above Exclusion Criteria: * Other rectal pathologies. * Patients less than 18yrs at diagnosis.
References
Publications (0)
Data not yet available