Clinical trial · Observational
Analysis of Patterns of Recurrence in Head and Neck Cancer Using Clinicopathomic Markers
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Here, the investigators will develop a clinicopathomic assay from biomarkers obtained from digital pathologies of resected whole-mount oral cavity and oropharyngeal squamous cell carcinoma (OCSCC and OPSCC) specimens with the goal of administering personalized novel image-guided therapies immediately after primary surgical management in OCSCC and OPSCC patients. The primary aim is to determine the association between clinicopathomic biomarkers and LRR. The secondary aim is to develop a clinicopathomic risk score (assay) such that a decision-support tool can be used by physicians for measuring the benefit of additional therapies (i.e. conventional chemotherapy +/- radiation or administering dose-escalated chemoradiation) in the adjuvant setting to reduce LRR rates.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Head and Neck Neoplasm | Head and Neck Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Squamous Cell Carcinoma of Head and Neck | Head and Neck Squamous Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Radiomic, pathomic, and clinical markers | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Time to locoregional recurrence
- timeFrame
- Up to 60 months
- description
- Evaluating the time until a recurrence event has occurred in the oral cavity or oropharyngeal region
Secondary outcomes (2)
- measure
- Time to distant metastasis
- timeFrame
- Up to 60 months
- description
- Evaluating onset of distant metastasis
- measure
- Time to death
- timeFrame
- Up to 60 months
- description
- Evaluating time to cancer-related death
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Participants must be men and women age 18+ * Confirmed diagnosis of oral cavity or oropharyngeal squamous cell carcinoma * Participants must have received or will undergo surgery to excise the primary oropharyngeal tumor. Exclusion Criteria: * Participants who had other primary cancers prior to oral cavity or oropharyngeal cancer
References
Publications (0)
Data not yet available