Clinical trial · Interventional

Microwave Ablation in Pulmonary Malignancies

CT_ Guided Percutaneous Microwave Ablation in Treatment of Pulmonary Malignancies

NCT04081181CI-TRIAL-00045671unknownN/AClinicalTrials.gov clinicaltrialsPublishedExplore in graph →

Summary

Brief summary (as posted)

Lung cancer remains to be an important global issue as it is the leading cause of cancer\_ related mortality for both men and women worldwide .Since more than two thirds of cases are diagnosed at an advanced stage,the survival rate of lung cancer is one of the lowest among all cancers.

Conditions

Conditions (1)

Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.

Condition (as posted)	Mapped entity	Match	Confidence
Lung Cancer	Malignant Lung Neoplasm	CURATED_EXACT	0.92

Interventions

Interventions (1)

Intervention	Type	Mapped drug	Match
Microwave ablation	Procedure	—	UNRESOLVED

Design

Arms and outcomes

Arms (1)

type
EXPERIMENTAL
label
CT_ guided percutaneous microwave ablation
description
The procedure will be done under anaesthesia by interventional radiologist
interventionNames
1. Procedure: Microwave ablation

Primary outcomes (3)

measure
Percentage of patients achieving adequacy of ablation
timeFrame
24 hours post ablation
description
Defined as perilesional circumferential solid area of ground glass opacification of \>4mm
measure
Percentage of patients achieving technical efficacy
timeFrame
1 month after ablation
description
Defined as lack of enhancement within the ablated zone

Eligibility

Eligibility (as posted)

Sex: All

Show eligibility criteria text

Inclusion Criteria:

* patient has good compliance and sign the informed consent.

  * patient with lung cancer who lost the opportunity of surgical resection.
  * patient has one or more metastatic lung nodules (not more than 5)

Exclusion Criteria:

* patient is pregnant or breast feeding .

  * patient with uncorrectable coagulopathy.
  * There are large blood vessels or important structures adjacent to lung lesion.
  * patient with more than five nodules

References

Publications (13)

BACKGROUNDFerlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015 Mar 1;136(5):E359-86. doi: 10.1002/ijc.29210. Epub 2014 Oct 9. PMID 25220842
BACKGROUNDJahangeer S, Forde P, Soden D, Hinchion J. Review of current thermal ablation treatment for lung cancer and the potential of electrochemotherapy as a means for treatment of lung tumours. Cancer Treat Rev. 2013 Dec;39(8):862-71. doi: 10.1016/j.ctrv.2013.03.007. Epub 2013 Apr 17. PMID 23601905
BACKGROUNDWeiser MR, Downey RJ, Leung DH, Brennan MF. Repeat resection of pulmonary metastases in patients with soft-tissue sarcoma. J Am Coll Surg. 2000 Aug;191(2):184-90; discussion 190-1. doi: 10.1016/s1072-7515(00)00306-9. PMID 10945362
BACKGROUNDSmith R, Pak Y, Kraybill W, Kane JM 3rd. Factors associated with actual long-term survival following soft tissue sarcoma pulmonary metastasectomy. Eur J Surg Oncol. 2009 Apr;35(4):356-61. doi: 10.1016/j.ejso.2008.01.004. Epub 2008 Feb 21. PMID 18294807
BACKGROUNDZhong L, Sun S, Shi J, Cao F, Han X, Bao X, You Q. Clinical analysis on 113 patients with lung cancer treated by percutaneous CT-guided microwave ablation. J Thorac Dis. 2017 Mar;9(3):590-597. doi: 10.21037/jtd.2017.03.14. PMID 28449467
BACKGROUNDBonichon F, Godbert Y, Gangi A, Buy X, Palussiere J. PET/Computed Tomography and Thermoablation (Radiofrequency, Microwave, Cryotherapy, Laser Interstitial Thermal Therapy). PET Clin. 2015 Oct;10(4):519-40. doi: 10.1016/j.cpet.2015.05.008. Epub 2015 Aug 1. PMID 26384598
BACKGROUNDShahzad Y, Louw R, Gerber M, du Plessis J. Breaching the skin barrier through temperature modulations. J Control Release. 2015 Mar 28;202:1-13. doi: 10.1016/j.jconrel.2015.01.019. Epub 2015 Jan 20.