Clinical trial · Interventional
Volatile Anaesthesia and Perioperative Outcomes Related to Cancer Feasibility Study
Volatile Anaesthesia and Perioperative Outcomes Related to Cancer (VAPOR-C): A Feasibility Study
NCT04074460CI-TRIAL-00058983VAPOR-CcompletedPhase 4ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
A multicentre, prospective randomized, active-controlled feasibility trial of volatile-based anaesthesia vs. propofol-based total intravenous anaesthesia to investigate the impact of anaesthesia on long-term (i.e. 5-years) patient cancer outcomes in patients undergoing elective major cancer surgery.
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer, Breast | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Cancer Colorectal | — | UNRESOLVED | — |
| Cancer, Lung | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Cancer Melanoma Skin | — | UNRESOLVED | — |
| Cancer, Other | Malignant Neoplasm | ALIAS | 0.85 |
| Cancer Prostate | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| isoflurane, sevoflurane or desflurane | Drug | — | UNRESOLVED |
| Propofol | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Propofol (TIVA)
- description
- Propofol-based total intravenous anaesthesia
- interventionNames
- Drug: Propofol
- type
- ACTIVE_COMPARATOR
- label
- Volatile
- description
- Volatile-based (isoflurane, sevoflurane or desflurane) general anaesthesia
- interventionNames
- Drug: isoflurane, sevoflurane or desflurane
Primary outcomes (2)
- measure
- To measure the ability to recruit eligible patients into the study.
- timeFrame
- 18 months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Male or female * Age 18-80 years * Elective surgery * Major cancer surgery expecting to last two or more hours, for: * Breast (mastectomy or segmentectomy plus sentinel node dissection) * Colorectal * Lung * Prostate * Melanoma (excision of melanoma plus lymph node dissection AND/OR skin flap construction * Other major cancer surgeries (e.g. oesophagectomy, head and neck cancer, etc.) Exclusion Criteria * Palliative surgery for end-stage disease with no curative intent * Emergency surgery * Extensive comorbid disease, i.e. American Society of Anesthesiologists (ASA) Score \> 4 * Age \<18 or \>80 years old * Refusal or inability to provide valid informed consent * Risk of severe postoperative nausea and vomiting (PONV risk score \>3) * Previous allergy or contraindication to either anaesthetic medication * Indication for gas induction of anaesthesia * Currently enrolled in another clinical trial unless agreed by the coordinating principal investigator and site principal investigator that co-enrolment can occur.
References
Publications (0)
Data not yet available
No reference posted for this study.