Clinical trial · Interventional
Matrix Metalloproteinases and Human Papillomavirus in Dysplasias and Cancers of the Cervix
Involvement of Matrix Metalloproteinases and Association With the Expression of Human Papillomavirus in Dysplasias and Cancers of the Cervix
NCT04072913CI-TRIAL-00115699MMP-HPVcompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study aims to compare the expression of matrix metalloproteinases and their tissue inhibitors between 4 groups of patients defined according to the severity of the cervical lesion.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cervix Cancer | — | UNRESOLVED | — |
| Dysplasia | — | UNRESOLVED | — |
| Papillomavirus Infections | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Vaginal samples (biopsies + vaginal smear) | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- OTHER
- label
- Control group
- description
- Study of the expression of matrix metalloproteinases and their tissue inhibitors
- interventionNames
- Other: Vaginal samples (biopsies + vaginal smear)
- type
- OTHER
- label
- Low grade lesion group
- description
- Study of the expression of matrix metalloproteinases and their tissue inhibitors
- interventionNames
- Other: Vaginal samples (biopsies + vaginal smear)
- type
- OTHER
- label
- High grade lesions group
- description
- Study of the expression of matrix metalloproteinases and their tissue inhibitors
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 20 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: For control group: * Age between 20 and 65 years * Patients hospitalized for partial or total removal of the cervix * Absence of cervical lesion observed on biopsy or hysterectomy * Free, informed and written consent, dated and signed by the patient and the investigator (at the latest before any examination required by the study) * Affiliate or beneficiary of a social security scheme For dysplasia and cancer group: * Age between 20 and 65 years * Cervical Intraepithelial Neoplasia or previously untreated cervical cancer * Free, informed and written consent, dated and signed by the patient and the investigator (at the latest before any examination required by the study) * Affiliate or beneficiary of a social security scheme Exclusion Criteria: For control group: * History of laser or conisation * Known antecedent of HIV infection * Congenital or acquired immunodepression * Long-term treatment with corticosteroids or immunosuppressants * Persons placed under the protection of justice For dysplasia and cancer group: * History of laser or conisation * Pre-treatment of invasive cancers by radiotherapy or chemotherapy * Known antecedent of HIV infection * Congenital or acquired immunodepression * Long-term treatment with corticosteroids or immunosuppressants * Persons placed under the protection of justice
References
Publications (0)
Data not yet available
No reference posted for this study.