Clinical trial · Observational
Gut Microbiota, Anastomotic Leak and Colorectal Cancer
NCT04071964CI-TRIAL-00077209unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a prospective study evaluating the relation between the gut microbiota composition, intestinal healing after colorectal surgery and colorectal cancer behavior. Our hypothesis is that the gut microbiota composition could predict poor intestinal healing in colorectal surgery, and that the gut microbiota might have an impact on colorectal cancer clinical behavior and may predict disease outcomes.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (4)
- label
- Groupe 1
- description
- Patients with colorectal cancer undergoing resection with anastomosis
- label
- Groupe 2
- description
- Patients with colorectal cancer undergoing resection without anastomosis (Abdominoperineal resection)
- label
- Groupe 3
- description
- Patients with rectal cancer without surgery ("Watch and wait")
- label
- Groupe 4
- description
- Control group consisting of patients who do not have surgical pathologies of the colon and rectum
Primary outcomes (1)
- measure
- Number of participants with an anastomotic leak
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria:
* Age 18 years and older
* CRC diagnosis
* Upcoming colonic and/or rectal resection with/without anastomosis
* Individuals without diseases of the colon and rectum (healthy controls)
Exclusion Criteria:
* Pregnancy
* Previous stoma
* Bowel surgery in the last 4 weeks prior to the surgery
Secondary objectives, inclusion criteria are as follows:
* Age 18 years and older
* Rectal cancer diagnosis with histopathological confirmation
* Abdominoperineal resection with terminal colostomy
* Expectative non-surgical management ("Watch and wait approach")References
Publications (0)
Data not yet available
No reference posted for this study.