Clinical trial · Observational
Adaptive CT Acquisition for Personalised Thoracic Imaging
ADAPT: Adaptive CT Acquisition for Personalised Thoracic Imaging: A Phase 1 Pilot Study on the Use of Respiratory Motion Guided 4DCBCT for Lung Cancer Radiotherapy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In this trial, Respiratory Motion Guided (RMG) 4DCBCT will be implemented for the first time on lung cancer patients. RMG-4DCBCT adapts the image acquisition as the patient's breathing changes (i.e. if the patient breathes faster, imaging data is acquired faster). By adapting the acquisition to the dynamic patient, personalised images of a patients lungs are able to be acquired for radiotherapy treatments.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer, Lung | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 4DCBCT images | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- 4DCBCT images
- description
- 4DCBCT images are acquired and assessed offline.
- interventionNames
- Device: 4DCBCT images
Primary outcomes (1)
- measure
- RMG-4DCBCT image guidance is feasible for lung cancer patients undergoing radiotherapy
- timeFrame
- 2 years
- description
- This will be achieved by performing (offline) analysis of the RMG-4DCBCT images obtained and scoring them on a scale of one (excellent quality for image guidance) to three (unsuitable for image guidance).
Secondary outcomes (1)
- measure
- To measure the extent of association between image quality and the patients' breathing conditions.
- timeFrame
- 2 years
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Have the ability to give informed consent * A diagnosis of lung cancer with an indication for radiotherapy either curative or palliative * Radiotherapy treatment involving the routine acquisition of CBCT for patient setup provided that 4DCBCT is to be acquired during the course of treatment. * At least two radiotherapy fractions during the course of treatment. Exclusion Criteria: * Pregnant women. * Patient who in the opinion of the treating physician could not tolerate the extra time on the treatment couch for two days of treatment.
References
Publications (1)
- DERIVEDLau BKF, Reynolds T, Keall PJ, Sonke JJ, Vinod SK, Dillon O, O'Brien RT. Reducing 4DCBCT imaging dose and time: exploring the limits of adaptive acquisition and motion compensated reconstruction. Phys Med Biol. 2022 Mar 7;67(6). doi: 10.1088/1361-6560/ac55a4. PMID 35172286