Clinical trial · Interventional
Epidural Intervention of Spinal Nerves With Tumor Necrosis Factor-Alpha Inhibitor
Treatment of Pain in Patients With Lumbar Spinal Stenosis By Epidural Intervention of Spinal Nerves With Local Anesthetic, Steroids and Tumor Necrosis Factor-Alpha Inhibitor Respectively：a Prospective Randomized Study
NCT04062474CI-TRIAL-00040136completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study is to assess the clinical efficacy of epidural injections with Tumor Necrosis Factor-Alpha(TNF-α) Inhibitor in patients with chronic radicular pain caused by lumbar spinal stenosis.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Spinal Stenosis | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Epidural Intervention with TNF-α inhibitor | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Epidural Intervention with Steroids
- description
- Epidural Intervention with Steroids
- interventionNames
- Procedure: Epidural Intervention with TNF-α inhibitor
Primary outcomes (2)
- measure
- visual analog scale
- timeFrame
- 6 months
- description
- visual analog scale(0-10 scores) is for pain, 0 represent no pain, 10 score represent the severe pain.
- measure
- Oswestry Disability Index
- timeFrame
- 6 months
- description
- Oswestry Disability Index is for movement function, Questionnaire examines
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 50 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosis of spinal stenosis with radicular pain at least 5 scores of VAS(ranging from 0 to 10). * Failed to improve symptom significantly through conservative treatment, including physiotherapy, chiropractic therapy, exercise, medication and bed rest. Exclusion Criteria: * lumbar surgery history, * spinal stenosis without radicular pain, * uncontrollable or unstable use of opioids, * uncontrolled mental illness, * pregnant or lactating women, * patients with a history of adverse reactions or possible adverse reactions to local anesthetics, etanercept or Steroids.
References
Publications (1)
- DERIVEDWei P, Xu Y, Yao Q, Wang L. Randomized trial of 3-drug combination for lumbar nerve root epidural injections with a TNF-alpha inhibitor in treatment of lumbar stenosis. Br J Neurosurg. 2020 Apr;34(2):168-171. doi: 10.1080/02688697.2020.1713990. Epub 2020 Jan 20. PMID 31955619