Clinical trial · Interventional
PTSD Mobile App for Cancer Survivors
Using a SMART Design to Optimize PTSD Symptom Management Strategies Among Cancer Survivors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to use a stepped-care approach in treating symptoms of posttraumatic stress disorder (PTSD). The information learned by doing this study may help us to develop some target treatments for PTSD symptoms in survivors of stem cell transplant. Participants in this study will be randomized to a mobile app or usual care. An assessment will be made after 4 weeks and a determination made of adding more intensive treatment. Participants will be asked to complete a questionnaire 4 times over a period of 6 months, at the time your participation is complete.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Posttraumatic Stress Disorder | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| CaDC + mCoaching | Behavioral | — | UNRESOLVED |
| Cancer Distress Coach (CaDC) App | Behavioral | — | UNRESOLVED |
| mCBT | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- EXPERIMENTAL
- label
- Cancer Distress Coach (CaDC)
- description
- Participants in this group will get the mHealth CaDC app, which will give them tools based on cognitive behavioral therapy principles to manage their stress.
- interventionNames
- Behavioral: Cancer Distress Coach (CaDC) App
- type
- EXPERIMENTAL
- label
- CaDC and mCoaching
- description
- Participants in this group will get both the CaDC app and weekly clinician support.
- interventionNames
- Behavioral: CaDC + mCoaching
- type
- EXPERIMENTAL
- label
- mCBT
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 85 Years
Show eligibility criteria text
Inclusion Criteria: * Completion of autologous or allogeneic HCT 1-5 years previously * Partial or complete remission (NED), may be receiving chemoprevention * Absence of severe psychological impairment (eg hospitalization for suicidality) * Approved for contact by oncologist * Able and willing to participate in a one-hour baseline interview * No prior CBT for PTSD * Owns a smart device with internet and email access * Able to read and write English * Significant PTSD symptoms as indicated by at least one of the following two criteria: probable cancer-related PTSD on the PCL5 by using the symptom cluster criteria; subthreshold or partial PTSD symptoms as determined by endorsement of reexperiencing cluster and less than or equal to 1 other symptom cluster Exclusion Criteria: * If the participant does not fulfill the inclusion criteria
References
Publications (2)
- DERIVEDSmith SK, Kuhn E, Somers TJ, Laber E, Manschot C, Sung AD, Kelleher SA, Majestic C, Syrjala KL, Mayer D, Giralt S, Pires A, Gebert RR, Owen JE, Yi JC, Applebaum AJ. Adaptive, Stepped-Care for Cancer-Related PTSD Symptoms in HCT Survivors: Results From a SMART Trial. Psychooncology. 2026 Aug;35(8):e70554. doi: 10.1002/pon.70554. PMID 42565481
- DERIVEDSmith SK, Manschot C, Kuhn E, Laber E, Somers TJ, Syrjala KL, Applebaum AJ. Assessing the utility of the PC-PTSD-5 as a screening tool among a cancer survivor sample. Cancer. 2024 Dec 1;130(23):4118-4126. doi: 10.1002/cncr.35504. Epub 2024 Aug 14. PMID 39141666