Clinical trial · Interventional
3D Printing for Nodule Localization
Three-dimensionally Printed Navigational Template for Localizing Small Pulmonary Nodules
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Implementation of lung cancer screening using low-dose computed tomography has increased the rate of detection of small peripheral pulmonary nodules. However, it is hard to localize these nodules by palpation because of their small volume and long distance to the nearest pleural surface. To further clarify the confounding factors, we developed our own 3D printing localization procedure. In contrast to traditional CT-G percutaneous puncture localization, our procedure was performed in the operating room without CT scan evaluation.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Pulmonary Nodule, Solitary | — | UNRESOLVED | — |
Interventions
Interventions (6)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 3D-printing guided | Procedure | — | UNRESOLVED |
| CT-guided | Procedure | — | UNRESOLVED |
| Indocyanine Green | Drug | — | UNRESOLVED |
| Intraoperative | Procedure | — | UNRESOLVED |
| Methylene blue | Drug | — | UNRESOLVED |
| Preoperative | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- 3D-printed template-guided(3D-G)
- description
- Intraoperative 3D-G methylene blue dye marking in the operating room
- interventionNames
- Procedure: 3D-printing guided
- Drug: Methylene blue
- Procedure: Intraoperative
- type
- ACTIVE_COMPARATOR
- label
- CT-guided(CT-G)
- description
- Preoperative localization is performed by CT-G indocyanine green marking in the radiology department
- interventionNames
- Procedure: CT-guided
- Drug: Indocyanine Green
- Procedure: Preoperative
Primary outcomes (1)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * a maximum target lung nodule diameter ≤20 mm; * a target nodule consolidation/tumor ratio (CTR) \<0.25, or a minimum distance from the outer edge of the nodule to the nearest pleural surface \>10 mm if the target nodule CTR was \>0.25. Exclusion Criteria: * Inability to comply with research protocols or research procedures * Any unstable systemic disease (including active infections, uncontrolled high blood pressure, unstable angina, angina pectoris that has started within the last 3 months, congestive heart failure (≥ New York Heart Association \[NYHA\] Level II ), cardiac infarction (6 months before enrollment), severe arrhythmia requiring medication, liver, kidney or metabolic disease * Active bleeding; Inability to withstand lying flat; Inability to cooperate through breathing during puncture * Pregnant or lactating women * Other circumstances that the investigator believes are not suitable for enrollment
References
Publications (0)
Data not yet available