Clinical trial · Observational
Evaluation of Urinary Exosomes Presence From Clear Cell Renal Cell Carcinoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Clear cell renal cell carcinoma is diagnosed by imaging, sometimes associated with biopsy. This diagnosis is expensive, invasive and sometimes late. The development of a simple biological test for diagnosis is essential. Exosomes are 30 to 150 nm membrane vesicles secreted into the extracellular space by various living cells. These exosomes can be isolated from biological fluids, including urine. The recent study of urinary exosomes is a promising topic for analyzing tumor markers in urine. The investigator's goal is to develop a reliable technique for detecting tumor exosomes in urine in patients with clear cell renal cell carcinoma. The analysis of urinary exosomes could provide a new liquid biopsy tool for the early diagnosis of clear cell renal cell carcinoma.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Clear Cell Renal Cell Carcinoma | Clear Cell Renal Cell Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Urinary sample | Biological | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Renal mass patients
- description
- Patients with renal mass requiring surgery (partial or total nephrectomy) will be included. They will have an urinary sample.
- interventionNames
- Biological: Urinary sample
- label
- Control patients
- description
- Control patients (without renal mass) will be included. They will have an urinary sample.
- interventionNames
- Biological: Urinary sample
Primary outcomes (1)
- measure
- Number of patients (with clear cell kidney cancer) with CD9+ and CA9+ exosomes by electron microscopy technique
- timeFrame
- At inclusion
- description
- Measured by analysis in electron microscopy technique of urinary sample.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: Patients: * All patients with renal mass requiring surgery (partial or total nephrectomy) * Social security affiliation * Signed informed consent Control : * Unscheduled nephrectomy * Social security affiliation * Signed informed consent Exclusion Criteria: * Insufficient volume of urine sample (\< 100 ml) * Patients with a urinary catheter * Patients under court-ordered guardianship or curators
References
Publications (1)
- DERIVEDLi G, Mallouk N, Flandrin P, Garcin A, Lambert C, Berremila SA, Habchi H, Mottet N. Presence of Urinary Exosomes for Liquid Biopsy of Clear Cell Renal Cell Carcinoma: Protocol for a Pilot Feasibility Study. JMIR Res Protoc. 2021 Jul 20;10(7):e24423. doi: 10.2196/24423. PMID 34283029