Clinical trial · Interventional
Bilateral Superficial Cervical Plexus Block in Thyroid/Parathyroid Surgery
Bilateral Superficial Cervical Plexus Block Combined With Intravenous Sedation Versus General Anesthesia in Selected Patients for Thyroid/Parathyroid Surgery ; a Prospective Randomized Control Trial
NCT04051099CI-TRIAL-00051956unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To compare efficacy and safety between bilateral superficial cervical plexus block combined with intravenous sedation (RA group) and general anesthesia (GA group) for thyroid and parathyroid operations. This study evaluates postoperative numerical pain score and systemic opioid requirement within 24 hours.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Benign Tumor of Thyroid | Benign Thyroid Gland Neoplasm | ALIAS | 0.90 |
| Hyperparathyroidism | — | UNRESOLVED | — |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Bilateral superficial cervical plexus block with 0.25% bupivacaine 8 ml each (total 16 ml) | Procedure | — | UNRESOLVED |
| Dexmedetomidine plus propofol infusion | Drug | — | UNRESOLVED |
| General anesthesia with endotracheal tube | Procedure | — | UNRESOLVED |
| Local infiltraion analgesia | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- bilateral cervical plexus block
- description
- bilateral superficial cervical plexus block with 0.25% bupivacaine 8 ml each (total 0.25% bupivacaine 16 mg)
- interventionNames
- Procedure: Bilateral superficial cervical plexus block with 0.25% bupivacaine 8 ml each (total 16 ml)
- Drug: Dexmedetomidine plus propofol infusion
- Procedure: Local infiltraion analgesia
- type
- EXPERIMENTAL
- label
- General anesthesia
- description
- General anesthesia with endotracheal intubation under total intravenous anesthesia (TIVA)
- interventionNames
- Drug: Dexmedetomidine plus propofol infusion
- Procedure: Local infiltraion analgesia
- Procedure: General anesthesia with endotracheal tube
Primary outcomes (6)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * American Society of Anesthesiologists (ASA) grade I-III, aged over 18 years * Elective thyroidectomy, thyroid lobectomy, parathyroidectomy Exclusion Criteria: * Language barrier or inability to communicate with the operating team * Allergy to local anaesthetic * Known substernal, retroesophageal or retrotracheal goiter * Thyroid cancer * Previous neck exploration or neck radiation * Recurrent laryngeal nerve paralysis * BMI ≥ 30
References
Publications (7)
- BACKGROUNDUeshima H, Hara E, Hiroshi O. RETRACTED: Successful cases of thyroid surgery performed under only bilateral cervical plexus blocks. J Clin Anesth. 2016 Nov;34:206. doi: 10.1016/j.jclinane.2016.04.014. Epub 2016 May 11. No abstract available. PMID 27687375
- BACKGROUNDWang Q, Li Z, Xu S, Li Y, Zhang X, Liu Q, Xia Y, Papadimos TJ, Xu X. Feasibility of ultrasound-guided capsule-sheath space block combined with anterior cervical cutaneous nerves block for thyroidectomy: an observational pilot study. BMC Anesthesiol. 2015 Jan 19;15(1):4. doi: 10.1186/1471-2253-15-4. eCollection 2015. PMID 25670918
- BACKGROUNDSuh YJ, Kim YS, In JH, Joo JD, Jeon YS, Kim HK. Comparison of analgesic efficacy between bilateral superficial and combined (superficial and deep) cervical plexus block administered before thyroid surgery. Eur J Anaesthesiol. 2009 Dec;26(12):1043-7. doi: 10.1097/EJA.0b013e32832d6913. PMID 19571762
- BACKGROUNDCai HD, Lin CZ, Yu CX, Lin XZ. Bilateral superficial cervical plexus block reduces postoperative nausea and vomiting and early postoperative pain after thyroidectomy. J Int Med Res. 2012;40(4):1390-8. doi: 10.1177/147323001204000417. PMID 22971490
- BACKGROUNDIngsathit A, Thakkinstian A, Chaiprasert A, Sangthawan P, Gojaseni P, Kiattisunthorn K, Ongaiyooth L, Vanavanan S, Sirivongs D, Thirakhupt P, Mittal B, Singh AK; Thai-SEEK Group. Prevalence and risk factors of chronic kidney disease in the Thai adult population: Thai SEEK study. Nephrol Dial Transplant. 2010 May;25(5):1567-75. doi: 10.1093/ndt/gfp669. Epub 2009 Dec 27. PMID 20037182
- BACKGROUNDSpanknebel K, Chabot JA, DiGiorgi M, Cheung K, Lee S, Allendorf J, Logerfo P. Thyroidectomy using local anesthesia: a report of 1,025 cases over 16 years. J Am Coll Surg. 2005 Sep;201(3):375-85. doi: 10.1016/j.jamcollsurg.2005.04.034. PMID 16125070
- Yerzingatsian KL. Thyroidectomy under local analgesia: the anatomical basis of cervical blocks. Ann R Coll Surg Engl. 1989 Jul;71(4):207-10.