Clinical trial · Observational
The Link Between Periodontitis, Smoking and Oral Cancer
Analysis of the Link Between Periodontitis, Smoking and Oral Cancer: Cohort Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Periodontitis is a widely prevalent disease worldwide that has serious public health consequences. Its prognosis includes tooth loss and edentulism, a condition that negatively affects chewing causing functional disability; and esthetics causing social impairment. Consequently, periodontitis may end up causing marked impairment of the quality of life of the affected patients, impairment of general health and increasing the dental care costs significantly. Changes in the oral mucosa arise by primary products resulting from tissue breakdown due to gingivitis. It then triggers the host cells to produce proteinases that mediate loss of marginal periodontal ligaments, apical migration of the junctional epithelium and apical spread of bacterial biofilm. Therefore, this research aims to identify the risk of smoking to both periodontitis and oral cancer, and the risk of periodontitis to oral cancer.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Chronic Periodontitis | — | UNRESOLVED | — |
| Oral Cancer | Malignant Lip and Oral Cavity Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| biopsy for oral cancer | Diagnostic Test | — | UNRESOLVED |
| periodontal examination | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Smokers
- interventionNames
- Diagnostic Test: biopsy for oral cancer
- Diagnostic Test: periodontal examination
- label
- non-Smokers
- interventionNames
- Diagnostic Test: biopsy for oral cancer
- Diagnostic Test: periodontal examination
Primary outcomes (1)
- measure
- Periodontitis
- timeFrame
- the 10 years of the study
- description
- arising of periodontitis or increase in the grade of an already existing case of periodontitis
Secondary outcomes (1)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients 18 years or older. Exclusion Criteria: * Patients with any systemic diseases. * Pregnant females. * Handicapped and mentally retarded patients. * Patients undergoing radiotherapy. * Patients having oral cancer
References
Publications (0)
Data not yet available