Clinical trial · Observational
Atrial Fibrillation After Surgery for Colorectal Cancer
Atrial Fibrillation After Resection (AFAR): A PROGRESS III Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study will report the incidence of atrial fibrillation after elective colorectal cancer resection in the over 65 age group. This will be used to validate a risk model for the development of post-operative atrial fibrillation. Eligible patients will undergo electrocardiogram based screening for atrial fibrillation, as well as brain natriuretic peptide tests prior to surgery. They will undergo 24 hour holter monitor prior to surgery, and at 30 and 90 days following surgery. The primary outcome will be occurrence of atrial fibrillation within 90 days of surgery. Secondary outcomes include quality of life change, use of hospital services for atrial fibrillation, and complications of atrial fibrillation. This will be used to validate the pre-existing model for prediction of atrial fibrillation.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Atrial Fibrillation New Onset | — | UNRESOLVED | — |
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 24 Hour Holter Monitor | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Main cohort
- description
- Will undergo surgery for colorectal cancer with curative intent as planned by local cancer multidisciplinary team.
- interventionNames
- Diagnostic Test: 24 Hour Holter Monitor
Primary outcomes (1)
- measure
- Incidence of atrial fibrillation within 90 days of colorectal cancer surgery, defined as ≥30 seconds of atrial fibrillation identified on a 24-hour cardiac monitor OR absence of p waves and irregularly irregular rhythm on an electrocardiogram
- timeFrame
- Within 90 days of colorectal cancer surgery
- description
- 24-hour recordings will be undertaken at 30 \& 90 days post surgery, and electrocardiogram on the day of discharge from hospital.
Secondary outcomes (3)
- measure
- Quality of life change (EQ-5D-5L (Euroqol-five dimension-five level)
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients aged ≥65 years old * Undergoing elective surgery for colorectal cancer with curative intent * No prior diagnosis of atrial fibrillation. * Willing to consent Exclusion Criteria: * Patients aged less than 65 years old * Pre-existing atrial fibrillation (persistent or paroxysmal) * Unable to provide informed consent * Life expectancy \<12 months * Prisoners * Known pregnancy * Lack mental capacity * Patients with limited English language as there is no funding to cover costs of translation of materials
References
Publications (2)
- BACKGROUNDHeywood EG, Drake TM, Bradburn M, Lee J, Wilson MJ, Lee MJ. Atrial Fibrillation After Gastrointestinal Surgery: Incidence and Associated Risk Factors. J Surg Res. 2019 Jun;238:23-28. doi: 10.1016/j.jss.2019.01.017. Epub 2019 Feb 5. PMID 30735962
- BACKGROUNDChebbout R, Heywood EG, Drake TM, Wild JRL, Lee J, Wilson M, Lee MJ. A systematic review of the incidence of and risk factors for postoperative atrial fibrillation following general surgery. Anaesthesia. 2018 Apr;73(4):490-498. doi: 10.1111/anae.14118. Epub 2017 Nov 4. PMID 29105078