Clinical trial · Observational
Approaches to Identify Early Biomarkers and Pathogenesis of Anthracycline Cardiotoxicity
Integrated Basis and Translational Approaches to Identify Early Biomarkers and Pathogenesis of Anthracycline Cardiotoxicity
NCT04036045CI-TRIAL-00096298withdrawnClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): No funding, no participation
Summary
Brief summary (as posted)
Early microRNAs (miRs) and Cardiac Magnetic Resonance (CMR)-derived strain analysis and detection of genes contributing to Anthracycline-Induced Cardiotoxicity (AIC) sensitivity and resistance will identify pediatric cancer patients most and least likely to develop AIC.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Childhood Cancer | Childhood Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Blood Draw | Other | — | UNRESOLVED |
| Cardiac MRI | Other | — | UNRESOLVED |
| Echocardiogram | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- CMR
- timeFrame
- From Baseline to one year after anthracycline therapy
- description
- 1\. Increased myocardial T2 relaxation time in the myocardium compared to baseline as measured by T2 mapping technique
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 9 Years
- Maximum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age (≥ 9years old) * Newly diagnosed with a malignancy that will receive ACs as part of their chemotherapy. * Parental/caregiver consent and subject assent to enrollment. Exclusion Criteria: * Subject has contraindications to CMR.\* * Subject requiring sedation for CMR * Subject too large to be safely accommodated by CMR * Pregnancy tests are done routinely prior to chemotherapy, if test is positive the patient will be excluded * Subject's serum creatinine above guidelines for adequate renal function. See table below: Age (years) Male Female 6-10 1.0 mg/dL 1.0 mg/dL 10-13 1.2 mg/dL 1.2 mg/dL 13-16 1.5 mg/dL 1.4 mg/dL \>16 1.7 mg/dL 1.4 mg/dL
References
Publications (0)
Data not yet available
No reference posted for this study.