Clinical trial · Observational
Role of Aerobic Exercise to Modulate Cardiotoxicity in Long Term Cancer Survivors Exposed to Anthracycline Therapy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Over 50% of the more than 270,000 childhood cancer survivors in the U.S. have been treated with anthracyclines and thus are at risk of developing cardiotoxicity. The impact of exercise training on LV structure has been extensively studied. Left ventricular hypertrophy and cardiac chamber enlargement with the accompanying ability to generate a large stroke volume are direct results of exercise training. Aerobic exercise therapy offers a non-pharmacological mechanism to modulate multiple gene expression pathways that may promote cardiac remodeling. No prior studies have investigated the efficacy of aerobic exercise in the prevention or treatment of anthracycline-induced cardiotoxicity. We hypothesize that exercise intervention leads to a reverse in adverse cardiac remodeling with improvement of global and regional myocardial function in patients exposed to anthracycline.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Cardiotoxicity | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Exercise program | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (2)
- measure
- Small increase in the left and right ventricular volume
- timeFrame
- Baseline to Week 12
- description
- Small increase in the left and right ventricular volume
- measure
- Small increase in left and right ventricular mass
- timeFrame
- Baseline to Week 12
- description
- Small increase in left and right ventricular mass
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 9 Years
- Maximum age
- 99 Years
Show eligibility criteria text
Inclusion Criteria: * Long-term childhood cancer survivors greater than 9 years of age\* * Exposed to anthracycline chemotherapy \* Age \> 9 years of age was chosen to avoid the need for general anesthesia or sedation Exclusion Criteria: * Contraindications to CMRI\* * Individuals needing sedation to complete the cMRI * Subject not able to perform stress test. * Pregnancy\*\* * Non-English speaking individuals * Orbital X-Ray confirmed to have metal in the eye or patient confirmed to have metal in the eye
References
Publications (1)
- DERIVEDToro-Salazar OH, Pescatello LS, Mah ML, Wilhelm C, Orsey AD, Berthod T, Mosha MH, Brimacombe M, Fan T, Wanner C, Slawinski M, Hor KN. A pilot exercise intervention to evaluate the role of cardiorespiratory fitness in modulating cardiotoxicity among childhood cancer survivors exposed to anthracycline therapy. Cardiooncology. 2025 Oct 9;11(1):88. doi: 10.1186/s40959-025-00388-5. PMID 41068874