Clinical trial · Interventional
Low-contrast Dose Liver CT Using Lean Body Weight Low Monoenergetic Images and Deep Learning-based Reconstruction
Low-contrast Dose Liver CT Using Lean Body Weight, Low Monoenergetic Images and Deep Learning-based Reconstruction for Hepatocellular Carcinoma
NCT04027556CI-TRIAL-00058237completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study aims to assess whether the acceptable image quality is achievable using low monoenergetic imaging of dual-energy CT with deep learning-based denoising, and low contrast media dose calculated based on lean body weight for the detection of hepatocellular carcinoma.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Body Weight | — | UNRESOLVED | — |
| Carcinoma, Hepatocellular | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| low dose CT contrast media - lean body weight | Other | — | UNRESOLVED |
| Standard dose CT contrast media | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- 50 keV DLD images of the LBW-based low-dose group
- description
- Low CT contrast media dose calculated based on lean body weight and low monoenergetic images of dual-energy CT with deep learning-based denoising
- interventionNames
- Other: low dose CT contrast media - lean body weight
- type
- ACTIVE_COMPARATOR
- label
- ADMIRE images of the standard-contrast dose group
- description
- Standard CT contrast media dose calculated based on total body weight and conventional images with full model-based iterative reconstruction
- interventionNames
- Other: Standard dose CT contrast media
Primary outcomes (1)
- measure
- HCC conspicuity
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
Show eligibility criteria text
Inclusion Criteria: * High risk group for developing HCC * Scheduled contrast-enhanced CT for HCC diagnosis or surveillance Exclusion Criteria: * not a high risk group for developing HCC * body mass index is equal to or larger than 30 kg/m\^2 * suspected HCC \> 5cm in diameter * received locoregional treatment or surgery for HCC within 3 months * congestive hepatopathy * no venous access on forearm * anticipated beam hardening artifact due to prosthesis * relative/absolute contraindication of contrast-enhanced CT
References
Publications (0)
Data not yet available
No reference posted for this study.