Clinical trial · Interventional
High Intensity Interval Training in Endometrial Cancer
Pre-operative Window Study of Interval Exercise Training as a Therapy for Endometrial Cancer
NCT04025229CI-TRIAL-00096563completedN/AResults postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This interventional trial recruits women with endometrial cancer to participate in high intensity interval training (HIIT) prior to their standard of care surgery. The study will evaluate tissue and blood to determine if HIIT training has anti-cancer effects. P
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Endometrial Cancer | Malignant Endometrial Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| HIIT exercise | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- HIIT exercise
- description
- Participants will perform HIIT exercises as instructed by the study team in the weeks prior to standard of care surgery
- interventionNames
- Behavioral: HIIT exercise
Primary outcomes (1)
- measure
- Change in Proliferative Markers in Endometrium Before and After HIIT Exercises
- timeFrame
- 3 years
- description
- Change in Ki-67 proliferation values within the HIIT intervention group between the initial biopsy and the surgical biopsy. The percentage of tumor cells that are positive for Ki-67, indicating they are in the active phases of the cell cycle (not resting). Low Ki-67 (\<10-15%): Slower-growing tumor. Intermediate (15-30%): Moderately proliferative. High (\>30%): Fast-growing, potentially more aggressive.
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with a diagnosis of endometrial cancer who are to undergo hysterectomy and staging * Between 40-75 years old * Body mass index of 30-50 kg/m2 * Endometrioid histology endometrial cancer * Presumed clinically early stage disease (disease confined to uterus only) * Have access to a Smart Phone * Have access to email * Agree to visit the exercise and sport science laboratory within 2 days of SOC visit for baseline testing if enrollment procedures cannot be done on the same day. Agree to visit clinic 2 (+/-2wks) weeks after surgery for SOC follow-up and post surgery visit, or willing to return to exercise and sport science laboratory 2 (+/-2wks) weeks post-surgery Exclusion Criteria: * Meets American College of Sports Medicine Guidelines for physical activity (150 minutes / week) * Currently doing HIIT * Hospitalization for a stroke, heart attack, or heart failure, or had surgery for blocked arteries in the past 3 months * Active diagnosis of psychosis or current uncontrolled substance abuse disorder * Insulin-dependent diabetes * Currently in another EC intervention * Severe dementia or other memory loss condition * Severe mental health disorder * Severely impaired hearing or speech * Inability to speak English * Musculoskeletal or neuromuscular condition that limits physical activity Any condition, in the opinion of the investigators, which would prohibit safe participation.
References
Publications (0)
Data not yet available
No reference posted for this study.