Clinical trial · Interventional
The Effect of Different Reconstruction Methods on Anterior Resection Syndrome
The Effect of Different Reconstruction Methods in Laparoscopic Anterior Rectal Resection on Postoperative Anterior Resection Syndrome：a Randomized Controlled Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The incidence of prerectal resection syndrome (LARS) after middle and low rectal cancer surgery is as high as 70%, which seriously affects the quality of life of patients. Studies have shown that colon pouch can reduce and alleviate LARS symptoms. However, most previous studies focused on open surgery, and the evaluation index lacked objectivity. Therefore, in the context of minimally invasive rectal cancer surgery, it is necessary to re-evaluate the value of improved surgical methods for the prevention of LARS, so as to improve the quality of life of patients.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Low Anterior Resection Syndrome | — | UNRESOLVED | — |
| Rectal Cancer | Malignant Rectal Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| transverse coloplasty pouch | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- coloplasty(CP)
- description
- After purse-string suture and ligation of the head of the stapler at the colonic end, 5cm away from the colonic end, 5cm longitudinal incision was made to the proximal end of the teniae coli in the anterior wall of the colon, transverse suture was performed, and the plasmomuscular layer was embedded, then end to end colon-rectum (or anal canal) anastomosis was performed
- interventionNames
- Procedure: transverse coloplasty pouch
- type
- NO_INTERVENTION
- label
- straight colorectal anastomosis (SCA)
- description
- End to end colon-rectum (or anal canal) anastomosis was performed routinely
Primary outcomes (1)
- measure
- anterior resection syndrome incidence
- timeFrame
- 1 year after surgery
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * 20 years old ≤80 years old, regardless of gender, signed informed consent, * BMI≤kg/m\^2, * Primary rectal lesions are pathologically diagnosed as rectal adenocarcinoma by endoscopic biopsy, * The distance between the tumor and the anal margin is 5cm to 12cm, * Preoperative tumor stage is T1-4N0-3M0,(according to AJCC-8th TNM tumor staging), * Normal anorectal function and LARS score ≤20. Exclusion Criteria: * Patients with inflammatory bowel disease, chronic constipation, irritable bowel syndrome and other intestinal diseases that may affect bowel function, * Patients with large tumors or extensive invasion of surrounding tissues and organs, TME is not applicable, * Long-term use of drugs (such as morphine) that may affect bowel function, * Patients with a history of abdominal, pelvic and anorectal surgery, * Patients with severe mental illness or who cannot be evaluated due to cultural or psychological reasons.
References
Publications (0)
Data not yet available