Clinical trial · Interventional
Liver Resection Modeling
Haemodynamic Modeling of Intrahepatic Blood Flow and Interaction With the Systemic Circulation
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Despite the medical and surgical progress of the last two decades, the selection of candidates for liver surgery remains based on old principles and insufficiently sensitive to fine-tune the gesture to patient-specific characteristics and make almost zero risks of postoperative liver failure (PLF) and death. It is therefore necessary to develop new tools that will make possible to predict the evolution of the postoperative portocaval gradient (difference of pressure between portal vein and vena cava), a well-known major risk factor for PLF. Hemodynamic modeling of the human liver during surgery will represent the purpose of this work in order to help the clinicians in their patient's selection and anticipation of postoperative risk.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Benign Liver Tumor | — | UNRESOLVED | — |
| Cirrhosis | — | UNRESOLVED | — |
| Malignant Tumor Liver | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| partial hepatectomy by laparotomy on healthy or pathologic parenchyma. | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- only one arm (resected patients)
- description
- liver resection group
- interventionNames
- Procedure: partial hepatectomy by laparotomy on healthy or pathologic parenchyma.
Primary outcomes (1)
- measure
- Estimation of the intraoperative portocaval post-hepatectomy gradient This pressure differential is performed before the parietal closure, after resection. We consider that the simulation is accurate if the difference with the measurement is ≤ 4 mmHg.
- timeFrame
- prtocaval gradient (difference between portal pressure and caval pressure assessend during surgery.
Secondary outcomes (3)
- measure
- Prediction of changes in cardiac output, hepatic artery and portal vein after hepatectomy.
- timeFrame
- Measures perormed during surgery
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adults ≥18 years old informed and consenting. * Partial hepatectomy by laparotomy (open approach). * Access to intraoperative measurements of vascular pressures and flow rates. * Major patients (age≥18 years) * Hepatic pathology requiring minor or major hepatectomy by laparotomy * Affiliation to a social security scheme * Written consent to participate in this research Exclusion Criteria: * Pregnant or breastfeeding women, * Patient under guardianship or curatorship * Refusal to participate in the study * Contraindication to performing MRI. * Patient already included in an interventional study
References
Publications (0)
Data not yet available