Clinical trial · Interventional
Screening for Colorectal Cancer in Average and High Risk Population
Screening for Colorectal Cancer in Average and High Risk Iraqi Population: A Pilot Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The existing evidence from epidemiological studies and randomized controlled trials has consistently assures the cost effectiveness and the influential role of screening in reducing incidence rates and deaths caused by Colorectal Cancer (CRC). Population based organized screening programmes, which should be considered an obligation that is not to be postponed, require valuable information that can be reliably extrapolated from well-designed pilot study conducted prior to programme implementation. The main objectives of the current pilot CRC screening project, named after "Al-Kindy College of Medicine", was to evaluate and explore the specific aspects of the intended population-based organized CRC screening programme, including: barriers affecting adherence to the programme, performance indicators of the proposed screening programme, the target population in which CRC screening is a legitimate healthcare priority, quality assurance of screening tests and colonoscopy services, and to propose an algorithm that will provide a clinically and logistically acceptable positivity rate.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Adenomatous Polyp of Colon | Colon Adenomatous Polyp | ALIAS | 0.90 |
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Colorectal Neoplasms | Colorectal Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (6)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Conventional Colonoscopy | Procedure | — | UNRESOLVED |
| Diltiazem hydrochloride 2%/Nitroglycerin rectal ointment | Drug | — | UNRESOLVED |
| FIT | Diagnostic Test | — | UNRESOLVED |
| Histopathological examinations of screen-detected lesions | Diagnostic Test | — | UNRESOLVED |
| Precolonoscopy cleansing regimen | Procedure | — | UNRESOLVED |
| Tribenoside 400 mg + lidocaine 40 mg suppositories | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Household-Open Invitation (HOI)
- description
- Precolonoscopy cleansing regimen and referral to conventional colonoscopy is based on Positive FIT (level ≥75ng/ml) in any of the two collected samples. Histopathological examinations of screen-detected lesions are reported and lesion with the worst prognosis is indicated as the final colonoscopic outcome used for evaluation purposes. Screenees with intermediate and high risk polyp were referred to a follow-up surveillance programme.Treatments were initiated with Diltiazem hydrochloride 2%/Nitroglycerin rectal ointment for anal fissure, and tribenoside 400 mg + lidocaine 40 mg suppositories for hemorrhoids. Positive FIT results in participants who were identified with no adenomas, advance adenomas, or adenocarcinomas are considered False-positive FIT (FP-FIT) results.
- interventionNames
- Diagnostic Test: FIT
- Procedure: Precolonoscopy cleansing regimen
- Procedure: Conventional Colonoscopy
- Diagnostic Test: Histopathological examinations of screen-detected lesions
- Drug: Tribenoside 400 mg + lidocaine 40 mg suppositories
- Drug: Diltiazem hydrochloride 2%/Nitroglycerin rectal ointment
- type
- ACTIVE_COMPARATOR
- label
- Recommendation By Physician (RBP)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 45 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * residents of Baghdad city * being ≥45 years of age with stop age of 80 years. Exclusion Criteria: * history of inflammatory bowel disease (IBD). * colonoscopy (CS)/flexible sigmoidoscopy (FS)/ double contrast barium enema (DCBE) performed within the last year. * persistent altered bowel habits. * chronic abdominal pain. * visible bleeding per rectum. * long term use of anticoagulant.
References
Publications (0)
Data not yet available