Clinical trial · Observational
Post-operative Ileus and Gut Microbiota
Post-operative Ileus of Colorectal Cancer Patients Associated With Perioperative Gut Microbiota
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Postoperative ileus (POI) is a common clinical condition after abdominal surgical procedure, leading to increased patient morbidity and prolonged hospitalisation.The mechanism of POI is not very clear until now. At the end of the 20th century, the inflammatory-mediated ileus hypothesis was introduced. But the initial trigger of the inflammatory cascade is unclear.Previous study demonstrate a clear association between colonic transit time, gut microbiota composition and urinary metabolic phenotype. Here the investigators suggest that the perioperative gut microbiota may contribute to POI.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Post-operative Ileus | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Fecal and blood samples collection for analysis | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Delayed transit
- description
- CRC patients with delayed gut transit recovery( first time defecation \>3 day )
- interventionNames
- Other: Fecal and blood samples collection for analysis
- label
- Normal transit
- description
- CRC patients with normal gut transit recovery( first time defecation \<=3 day )
- interventionNames
- Other: Fecal and blood samples collection for analysis
Primary outcomes (2)
- measure
- Change in gut microbiome dynamics in colorectal cancer patients during the perioperative period between two groups
- timeFrame
- The day before operation day, the first to the 10th day after operation (everyday the patient's faeces will be collected for microbiome analysis, if the patient has no faeces,we will skip that day to next day for fecal collection)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 35 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Requirements of informed consent and assent of participant, parent or legal guardian as applicable * Patients with colorectal cancer scheduled for radical coloproctectomy and between the age of 35 and 80 years old without considering sex. * Patients with BMI= 18.5-23.9 Exclusion Criteria: * Patients with colorectal cancer with distant metastasis * Chronic renal diseases and hepatic cirrhosis * Chronic ischemic heart disease with unstable angina, chronic heart failure at class III or IV and acute myocardial infarction in the last 6 months * Individuals with a history of Chronic diarrhea * Individuals with a history of Diabetes mellitus * Individuals with a history of Hypertension * Individuals with a history of autoimmune diseases * Use of antibiotics and probiotics 3 mouth before samples collection * Individuals with a history of abdominal operation due to any reason * Individuals with any history of cancer other than colorectal cancer * Individuals with Inflammatory bowel disease
References
Publications (0)
Data not yet available