Clinical trial · Interventional
The Internet Therapy for Depression Trial
The Internet Therapy for Depression Trial (INTEREST): A Doubly-randomized, Patient-preference, Controlled Feasibility Trial Comparing iACT, iCBT, and Attention Control
NCT04009135CI-TRIAL-00053893INTERESTcompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The objective of this trial is to collect data on the feasibility, acceptability, and preliminary effectiveness of internet delivered Cognitive Beaviour Therapy (iCBT) and Acceptance and Commitment Therapy (iACT) interventions tailored towards the treatment of depression and chronic pain using a doubly-randomized, attention-controlled, non-blinded, patient-preference design.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Chronic Pain | — | UNRESOLVED | — |
| Major Depressive Disorder | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Attention Control (AC) | Other | — | UNRESOLVED |
| internet delivered cognitive behavioural therapy (iCBT) | Behavioral | — | UNRESOLVED |
| online delivered acceptance and commitment therapy (iACT) | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- internet delivered cognitive behavioural therapy (iCBT)
- description
- The intervention comprises 7 weekly online modules available through Therapist Assisted Online (TAO), including: 1) psychoeducation about chronic pain and depression; 2) thoughts and feelings; 3) understanding stress and relaxation; 4) unhealthy and healthy thoughts; 5) layers of thinking; 6) core beliefs; and 7) relationship, lifestyle, problem solving, and relapse prevention. Online content is supplemented with weekly coaching sessions performed via video-conference with doctoral students of Clinical Psychology.
- interventionNames
- Behavioral: internet delivered cognitive behavioural therapy (iCBT)
- type
- EXPERIMENTAL
- label
- online delivered acceptance and commitment therapy (iACT)
- description
- The intervention comprises 7 weekly online modules available through Therapist Assisted Online (TAO), including: 1) psychoeducation about chronic pain and depression; 2) introduction to ACT; 3) cognitive fusion and defusion; 4) thinking mind versus observing mind \& acceptance; 5) mindfulness; 6) values; and 7) taking action. Online content is supplemented with weekly coaching sessions performed via video-conference with doctoral students of Clinical Psychology.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Fluent in English * 18 years of age or older * have a primary diagnosis of chronic non-cancer pain. * meet DSM-5 criteria for a diagnosis of major depressive disorder * have access to the internet, email, and telephone * can commit to the demands and timelines of the trial. * Given high comorbidity in this population, patients with sleep disturbance or comorbid anxiety will also be eligible to participate. Exclusion Criteria: * diagnosis of cognitive impairment (e.g., dementia) * active suicidal ideation * severe psychopathology (e.g., schizophrenia) * unable to sign a safety contract for the duration of the trial * concurrent participation in psychotherapy.
References
Publications (1)
- DERIVEDBell LV, Cornish P, Flusk D, Garland SN, Rash JA. The INternet ThERapy for deprESsion Trial (INTEREST): protocol for a patient-preference, randomised controlled feasibility trial comparing iACT, iCBT and attention control among individuals with comorbid chronic pain and depression. BMJ Open. 2020 Feb 28;10(2):e033350. doi: 10.1136/bmjopen-2019-033350. PMID 32114466