Clinical trial · Interventional
Inflammatory Response After One-lung Ventilation According to Ventilation Methods
Comparison of the Inflammatory Response After One-lung Ventilation With Positive Ventilation and Self-respiration
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Unlike conventional thoracic surgery performed under general anesthesia with tracheal intubation, non-intubated thoracic surgery with sedation and regional anesthesia has been performed recently. Non-intubated thoracic surgery is expected to reduce the postoperative inflammatory changes by maintaining more physiologic status during the operation compared to intubated thoracic surgery. The aim of this study was to compare perioperative immunological changes between intubated and non-intubated thoracic surgery.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Ventilation method | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- NO_INTERVENTION
- label
- Intubated
- description
- The patient was intubated with a left-sided double-lumen endobronchial tube. The protective ventilation was performed as follows: a tidal volume of 6 mL/kg predicted body weight, I:E ratio of 1:2, a respiratory rate to maintain PaCO2 within 35 to 45 mmHg, and positive end-expiratory pressure at 5 cmH2O. If the airway pressure exceeded 25 cmH2O, tidal volume was adjusted.
- type
- EXPERIMENTAL
- label
- Non-intubated
- description
- The patients were oxygenated via facial mask with O2 5\~10 L/min during the whole procedure. The end-tidal carbon dioxide (EtCO2) was measured by insertion of a detector inside one of the nostrils. Respiration rate was maintained between 12 and 20 breaths/min with adjustment of anesthetics.
- interventionNames
- Other: Ventilation method
Primary outcomes (1)
- measure
- Interleukin (IL)-6
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * elective video-assisted thoracoscopic surgery (VATS) lobectomy * 20 \< age \< 75 * American Society of Anesthesiologists (ASA) classification I\~II Exclusion Criteria: * preoperative inflammation (CRP\>10ng/㎖, WBC\>10,000/mm3, body temperature \>38℃) * steroid administration within 1 month * hematologic / autoimmune disease * congestive heart failure (NYHA class III\~IV) or significant arrhythmia * severe obstructive / restrictive pulmonary disease * previous history of thoracic surgery * BMI \>28kg/m2 * expected difficult airway
References
Publications (1)
- DERIVEDJeon J, Sung S, Moon Y, Koo J, Hyun K, Han K, Hwang W. Comparison of early postoperative cytokine changes in patients undergoing intubated and non-intubated thoracic surgery: a randomized controlled trial. Interact Cardiovasc Thorac Surg. 2021 Apr 8;32(3):343-350. doi: 10.1093/icvts/ivaa265. PMID 33831216