Clinical trial · Interventional
Effect of Dexmedetomidine on the Inflammatory Response After One-lung Ventilation
Effect of Dexmedetomidine on the Inflammatory Response in Patients Undergoing Lung Resection Surgery
NCT04007341CI-TRIAL-00039332completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The postoperative inflammatory response is significant in lung resection surgery because of major operation and one-lung ventilation. Dexmedetomidine has been shown to reduce pro-inflammatory cytokine levels and improve clinical outcomes. The aim of this study was to determine the effects of dexmedetomidine on inflammatory responses after lung resection surgery.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dexmedetomidine | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- NO_INTERVENTION
- label
- Saline group
- description
- Patients in the saline group were infused with an identical volume of normal saline.
- type
- EXPERIMENTAL
- label
- Dexmedetomidine group
- description
- Patients in the dexmedetomidine group were infused with a loading dose of dexmedetomidine (1.0 mcg/kg over 10 min) and were thereafter infused at a rate of 0.5 mg/kg/h.
- interventionNames
- Drug: Dexmedetomidine
Primary outcomes (1)
- measure
- Interleukin (IL)-6
- timeFrame
- 24 hours after surgery
- description
- Blood samples were collected from the antecubital vein
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * elective video-assisted thoracoscopic surgery (VATS) lobectomy * 20 \< age \< 75 * American Society of Anesthesiologists (ASA) classification I\~II Exclusion Criteria: * preoperative inflammation (CRP\>10ng/#, WBC\>10,000/mm3, body temperature \>38#) * steroid administration within 1 month * hematologic / autoimmune disease * congestive heart failure (NYHA class III\~IV) or significant arrhythmia * severe obstructive / restrictive pulmonary disease * previous history of thoracic surgery
References
Publications (0)
Data not yet available
No reference posted for this study.