Clinical trial · Observational
MRI Radiomics Assessing Neoadjuvant Chemotherapy in Breast Cancer to Predict Lymph Node Metastasis and Prognosis(RBC-02)
Novel Radiomics Signature on MRI Before and After Neoadjuvant Chemotherapy in Breast Cancer to Predict Axillary Lymph Node Metastasis and Prognosis (RBC-02)
NCT04004559CI-TRIAL-00045711RBC-02unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study is aimed to illustrate whether Radiomics combining multiparametric MRI before and after neoadjuvant chemotherapy (NACT) with clinical data is a good way to predict axillary lymph node metastasis and prognosis in invasive-breast-cancer.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Axillary Lymph Node | — | UNRESOLVED | — |
| Invasive Breast Cancer | Invasive Breast Carcinoma | ALIAS | 0.90 |
| Neoadjuvant Chemotherapy | — | UNRESOLVED | — |
| Prognosis | — | UNRESOLVED | — |
| Radiomics | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| No interventions | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- Sun Yat-Sen Memorial Hospital of Sun Yat-sen University
- description
- Cohort of Sun Yat-Sen Memorial Hospital of Sun Yat-sen University is the training cohort.
- interventionNames
- Other: No interventions
- label
- Sun Yat-sen University Cancer Center
- description
- Cohort of Sun Yat-sen University Cancer Center is validation cohort 1.
- interventionNames
- Other: No interventions
- label
- Tungwah Hospital of Sun Yat-Sen University
- description
- Cohort of Tungwah Hospital of Sun Yat-Sen University is validation cohort 2.
- interventionNames
- Other: No interventions
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: 1. Primary lesion diagnosed as invasive breast cancer; 2. Imaging examination confirmed no distant organ metastasis; 3. Received neoadjuvant chemotherapy for drugs such as taxanes, anthracyclines, and platinum as planned; 4. Completed breast MRI examination before or after neoadjuvant chemotherapy; 5. Accepted breast cancer surgery and axillary lymph node dissection; 6. Eastern Cooperative Oncology Group performance status 0-2. Exclusion Criteria: 1. History of ipsilateral axillary or breast surgery; 2. Inflammatory breast cancer; 3. Bilateral breast cancer; 4. Malignant tumor history in 5 years; 5. Patients with cervical or contralateral axillary lymph node metastasis; 6. Incomplete imaging or medical history data.
References
Publications (0)
Data not yet available
No reference posted for this study.