Clinical trial · Interventional
The Pathogenesis of Chronic Diarrhoea After Treatment for Cancer in Cecum and the Ascending Colon
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Many patients suffer from chronic diarrhoea after surgical treatment for cancer in the right side of the colon. The investigators' main hypothesis is that colon cancer patients with chronic diarrhoea have a higher risk of bile acid malabsorption compared with colon cancer patients without diarrhoea. The investigators also expect that a part of the cases of bile acid malabsorption is caused by underlying bacterial overgrowth in the small bowel. The investigators assume that patients with severe bile acid malabsorption have a lower value of FGF19 in the blood compared to patients with moderate or none bile acid malabsorption. Furthermore, it is assumed that patients with chronic diarrhoea and documented bile acid malabsorption after surgical treatment for right-sided colon cancer will get improved bowel function when treated with a bile acid binder, or antibiotics in case of bacterial overgrowth.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colon Adenocarcinoma | Colon Adenocarcinoma | ONTOLOGY_EXACT | 0.98 |
| Diarrhea | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Antibiotics | Drug | — | UNRESOLVED |
| Bile Acid Binder | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- Positive breath test
- description
- Patients with a positive breath test are treated with antibiotics.
- interventionNames
- Drug: Antibiotics
- type
- ACTIVE_COMPARATOR
- label
- Positive SeHCAT scan
- description
- Patients with a positive SeHCAT scan are treated with a bile acid binder.
- interventionNames
- Drug: Bile Acid Binder
- type
- NO_INTERVENTION
- label
- No intervention
- description
- Patients with a normal breath test and a normal SeHCAT scan receive no intervention.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Primary adenocarcinoma in cecum or the ascending colon * Right-sided hemicolectomy * Understanding, speaking and reading Danish Exclusion Criteria: * Previous major gastrointestinal, urological or gynaecological surgery or oncological treatment * Radiation therapy * Recurrence of colon cancer * Metastasis * Permanent stoma * Pregnancy * Reduced cognitive level that makes it plausible that the patient do not understand the study or is not capable of participation
References
Publications (0)
Data not yet available