PIPAC With Nab-paclitaxel and Cisplatin in Peritoneal Carcinomatosis

Inclusion criteria:

* Informed consent as documented by signature
* ≥18 years,
* psychologically able to follow the trial procedures
* with peritoneal carcinomatosis from pancreatic, oesogastric, epithelial ovarian cancers or primitive peritoneal mesothelioma,
* ECOG 0, 1 or 2,
* Life expectancy \> 3 months,
* Not candidate for surgical cytoreduction and IP/HIPEC based on expert multidisciplinary board
* who received at least one line of chemotherapy and for whom standard therapies have been exhausted or not feasible. patients with residual disease following the first line of therapy or Following secondary debulking are eligible.

Exclusion criteria:

* Predominant extra-peritoneal metastases at the discretion of the study team after discussion at the multidisciplinary board,
* Bowel obstruction, active gastro-duodenal ulcer or ongoing abdominal infection (bacterial, viral or fungal),
* Chemotherapy or surgery within the last two weeks prior to enrollment,
* Previous intra-abdominal chemotherapy,
* General or local (abdominal) contra-indications for laparoscopic surgery
* Known allergy to cisplatin or other platinum-containing compounds or to nab-paclitaxel,
* Severe renal impairment (calculated GFR (CKD-EPI) \< 60 mL/min/1.73 m2), myelosuppression (platelet count \< 100.000/μl, hemoglobin \< 9g/dl, neutrophil granulocytes \< 1.500/ml), International Normalized Ratio (INR) \> 2, severe hepatic (Serum total bilirubin \> 1.5 mg/dl), respiratory or neurologic impairment (grade 3), severe myocardial insufficiency (NYHA class \> 2), recent myocardial infarction, severe arrhythmias,
* Pregnancy or breastfeeding, women who can become pregnant must ensure effective contraception.
* Known or suspected non-compliance, inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant,
* Has a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the trial, interfere with the subject's participation for the full duration of the trial, or is not in the best interest of the subject to participate, in the opinion of the treating investigator.