Clinical trial · Interventional
Comparison of 2 Types of Cervical Specimens in Patients With a Pathological Screening Smear
Endocervical Curettage Performed With a Kevorkian Curette Versus Cytobrush in Patients With ASC-H, LSIL, ASCUS HPV Positive and Non-contributory Colposcopy (ZT3) Smear or Atypical Pap Smear With Positive HPV Test
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): default inclusion
Summary
Brief summary (as posted)
The recommendations on the method and the realization of the cervico-uterine smears are clear. With regard to performing endocervical curettage, several methods are possible without precise consensus. In general, the Kevorkian curette is widely used. However, it is often reported by doctors and patients that curettage is painful. Some articles show that the cytobrush would be less painful. While keeping a percentage of correct curettage failures, it is sought to show that the cytobrush would improve the comfort of the patient during curettage.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cervical Cancer | Malignant Cervical Neoplasm | CURATED_EXACT | 0.92 |
| Pathological Screening Smear | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Cytobrush | Device | — | UNRESOLVED |
| Kevorkian curette | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Kevorkian curette
- interventionNames
- Device: Kevorkian curette
- type
- EXPERIMENTAL
- label
- Cytobrush
- interventionNames
- Device: Cytobrush
Primary outcomes (1)
- measure
- Percentage of sampling failures
- timeFrame
- once time, Baseline
- description
- Unsatisfactory sampling will be defined by a specimen containing \<20 endocervical cells, \<3 epithelial flaps, and one specimen without stroma.
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 25 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Women followed for a cervical pathology requiring endocervical curettage: * AGC type (glandular cell atypia) with positive HPV test * Frottis ASC-H, LSIL, ASCUS HPV + with non-contributive colposcopy (ZT3) Exclusion Criteria: * Pregnant woman * Women under the age of 25 or over 65 * Stenosis of the neck complete or tight not allowing the possible insertion of a curette (inadequate size cervical orifice and material) * Presence of a vaginal lesion on colposcopic examination
References
Publications (0)
Data not yet available