Clinical trial · Observational
Use of Multiparametric MRI in the Management of Head and Neck Cancer: a Prospective Analysis
Use of Multiparametric Magnetic Resonance Imaging in the Management of Head and Neck Cancer: a Prospective Analysis
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The investigators aim to validate specific MRI parameters that could improve diagnostic accuracy of metastatic cervical lymph nodes in patients with a squamous cell carcinoma in the head and neck region. Moreover, we aim to explore specific MRI parameters that could improve diagnostic accuracy of bone invasion and tumour relapse, as well as predict treatment response and survival in this target population.
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Bone Invasion | — | UNRESOLVED | — |
| Cervical Lymph Node | — | UNRESOLVED | — |
| Head and Neck Cancer | Malignant Head and Neck Neoplasm | ALIAS | 0.90 |
| Multiparametric MRI | — | UNRESOLVED | — |
| Treatment Response | — | UNRESOLVED | — |
| Tumour Relapse | Head and Neck Neoplasm | PROBABILISTIC | 0.70 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- affected
- description
- All patients with a histologically confirmed squamous cell carcinoma in the head and neck region
- label
- control
- description
- Whartin tumour or pleomorphic adenoma of the parotid gland without malignant transformation
Primary outcomes (3)
- measure
- discriminatory value of MRI perfusion curve between tumoural and non-tumoural cervical lymph nodes
- timeFrame
- preoperative
- description
- MRI parameters will be considered validated if they enable differentiation between a metastatic cervical lymph node and a non-tumoural lymph node, as based on the final pathology report as the 'gold standard'
- measure
- discriminatory value of MRI ADC value between tumoural and non-tumoural cervical lymph nodes
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients who received a pretreatment multiparametric MRI according to a standardized protocol * Histopathologically proven SCC in the HN region (affected group) * Histopathologically proven Whartin tumour or pleomorphic adenoma in the HN region without malignant transformation (control group) * Patients in whom a or multiple clearly distinguishable cervical lymph node(s) can be observed radiologically, and which can be correlated unambiguously with the pathology report Exclusion Criteria: * not fulfilling abovementioned criteria * thyroid or skin cancer * considerable artefact on MRI * previously surgery, irradiation or chemotherapy in the HN region
References
Publications (0)
Data not yet available