Clinical trial · Interventional
Linked Color Imaging vs White Light Imaging for Detection of Gastric Cancer Precursors
A Prospective Randomized Study of Linked Color Imaging and Conventional White Light Imaging in Gastroscopy for the Detection of Gastric Cancer Precursors
NCT03990025CI-TRIAL-00074044completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study aims to examine the use of Linked Color Imaging in detection of gastric cancer precursors, as well as oesophageal and duodenal lesions.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Barrett Esophagus | — | UNRESOLVED | — |
| Early Gastric Cancer | Early Gastric Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Linked Color Imaging | Diagnostic Test | — | UNRESOLVED |
| White Light Imaging | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- OTHER
- label
- Linked Color Imaging - White Light Imaging
- description
- Participant undergoes gastroscopy via Linked Color Imaging first, then followed by White Light Imaging
- interventionNames
- Diagnostic Test: Linked Color Imaging
- Diagnostic Test: White Light Imaging
- type
- OTHER
- label
- White Light Imaging - Linked Color Imaging
- description
- Participant undergoes gastroscopy via White Light Imaging first, then followed by Linked Color Imaging
- interventionNames
- Diagnostic Test: Linked Color Imaging
- Diagnostic Test: White Light Imaging
Primary outcomes (3)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 50 Years
- Maximum age
- 100 Years
Show eligibility criteria text
Inclusion Criteria: * Patients aged 50 years and above * Patients undergoing gastroscopy for symptom evaluation * Patients undergoing gastroscopy for surveillance of known intestinal metaplasia Exclusion Criteria: * Emergent gastroscopy performed for suspected acute GI bleeding * Patients with previous surgical/endoscopic resection in stomach * Patients with deranged coagulation and platelet function (INR\>1.5, Plt\<50) * Patients with severe comorbid illness (ASA 3 and above)
References
Publications (4)
- RESULTDohi O, Yagi N, Onozawa Y, Kimura-Tsuchiya R, Majima A, Kitaichi T, Horii Y, Suzuki K, Tomie A, Okayama T, Yoshida N, Kamada K, Katada K, Uchiyama K, Ishikawa T, Takagi T, Handa O, Konishi H, Naito Y, Itoh Y. Linked color imaging improves endoscopic diagnosis of active Helicobacter pylori infection. Endosc Int Open. 2016 Jul;4(7):E800-5. doi: 10.1055/s-0042-109049. PMID 27556101
- RESULTPaggi S, Mogavero G, Amato A, Rondonotti E, Andrealli A, Imperiali G, Lenoci N, Mandelli G, Terreni N, Conforti FS, Conte D, Spinzi G, Radaelli F. Linked color imaging reduces the miss rate of neoplastic lesions in the right colon: a randomized tandem colonoscopy study. Endoscopy. 2018 Apr;50(4):396-402. doi: 10.1055/a-0580-7405. Epub 2018 Mar 14. PMID 29539651
- RESULTYao K. The endoscopic diagnosis of early gastric cancer. Ann Gastroenterol. 2013;26(1):11-22. PMID 24714327
- RESULTSun X, Dong T, Bi Y, Min M, Shen W, Xu Y, Liu Y. Linked color imaging application for improving the endoscopic diagnosis accuracy: a pilot study. Sci Rep. 2016 Sep 19;6:33473. doi: 10.1038/srep33473. PMID 27641243