Olaratumab Plus Trabectedin in Advanced Soft-tissue Sarcoma Patients Soft-tissue Sarcoma Patients

Inclusion Criteria:

1. Patients must provide written informed consent prior to performance of study specific procedures and must be willing to comply with treatment and follow-up.
2. Age: 18-80 years.
3. Histologic diagnosis of soft tissue sarcoma: liposarcoma (dedifferentiated and myxoid/round cell), leiomyosarcoma, undifferentiated pleomorphic sarcoma, synovial sarcoma confirmed, before enrolment confirmation, by central pathology review by a paraffin embedded tumor tissue.
4. Metastatic/advanced disease in progression in the last 6 months.
5. Patients had previously received at least anthracyclines if clinically indicated.

   Previous olaratumab administration is allowed.
6. Measurable disease according to RECIST 1.1 criteria.
7. ECOG Performance Status of 0-1.
8. Adequate hepatic, renal, cardiac, and hematologic function.
9. Laboratory tests as follows: Haemoglobin \>9g/dl, Absolute neutrophil count ≥ 1,500/mm³, Platelet count ≥ 100,000/mm³, Total Bilirubin ≤ 1.5 mg/dL, PT≤ 1.5 ULN and INR ≤ 1.5, AST and ALT ≤ 2.5 times upper limit of normal, Creatinine

   ≤ 1.5 mg/dL Calcium ≤ 12 mg/dL and Blood glucose \< 150 mg/dL, Urine protein assessment: \<2+, and/or \<3.5g protein/24h.
10. Left ventricular ejection fraction ≥ 50% by echocardiogram or MUGA scan.
11. Having a central venous portal is mandatory before treatment initiation.
12. Females of childbearing potential must have a negative serum or urine pregnancy test within 7 days prior to enrollment. Females of child-bearing potential and males and must agree to use highly effective contraceptive precautions during the trial and up to 6 months following the last dose of study drug. A highly effective method of birth control is defined as one that results in a low failure rate (that is, \<1% per year) when used consistently and correctly, such as implants, injectables, combined oral contraceptives, some intrauterine contraceptive devices (IUDs), sexual abstinence, or a vasectomized partner.

Exceptions: Females not of child-bearing potential due to surgical sterilization (at least 6 weeks following surgical bilateral oophorectomy with or without hysterectomy or tubal ligation) confirmed by medical history or menopause. A "postmenopausal woman" is a woman meeting either of the following criteria:

* spontaneous amenorrhea for at least 12 months, not induced by a medical condition such as anorexia nervosa and not taking medications during the amenorrhea that induced the amenorrhea (for example, oral contraceptives, hormones, gonadotropin releasing hormone, antiestrogens, selective estrogen receptor modulators (SERMs), or chemotherapy
* spontaneous amenorrhea for 6 to 12 months and a follicle-stimulating hormone (FSH) level \>40 mIU/mL

Exclusion criteria:

1. More than 2 previous lines of chemotherapy for advanced disease. Previous trabectedin not allowed.
2. Hipersensitivity to olaratumab.
3. The following histologies are not included: Ewing Sarcoma, extraskeletal osteosarcoma, extraskeletal myxoid chondrosarcoma, Kaposi's sarcoma, rhabdomyosarcoma and gastrointestinal stromal tumor (GIST).
4. Uncontrolled intercurrent illness including (not limited to): symptomatic congestive heart failure (CHF) (New York Heart Association \[NYHA\] III/IV), unstable angina pectoris or coronary angioplasty, or stenting within 24 weeks prior to registration, unstable cardiac arrhythmia (ongoing cardiac dysrhythmias of NCI-CTCAE\] version 5.0 Grade \>= 2), known psychiatric illness that would limit study compliance, intra-cardiac defibrillators, known cardiac metastases, or abnormal cardiac valve morphology (\>= Grade 3).
5. Positive test for hepatitis B virus surface antigen (HBV sAg) or hepatitis C virus ribonucleic acid (HCV antibody) indicating acute or chronic infection.
6. Other disease or illness within the past 6 months, including any of the following:

   * Myocardial infarction
   * Coronary or peripheral artery bypass graft
   * Cerebrovascular accident or transient ischemic attack
   * Pulmonary embolism
7. The patient has electively planned or will require major surgery during the course of the study
8. Social situation that would preclude study compliance.
9. Prolonged QTc interval (i.e., QTc \> 450 msec for males or QTc \> 470 msec for females) on baseline ECG.
10. Hemorrhage ≥ Grade 3 in the past 4 weeks.
11. Females who are pregnant or breast-feeding.