Clinical trial · Observational
Multi-center Clinical Application of Hangzhou Criteria in Liver Transplantation for Hepatocellular Carcinoma
Multi-center Clinical Application of Hangzhou Criteria in Liver Transplant Candidate Selection for Hepatocellular Carcinoma
NCT03985644CI-TRIAL-00039075unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Liver transplantation is an optimal radical therapy for selected patients with hepatocellular carcinoma. Hangzhou criteria could safely and effectively expand Milan criteria with expanded population and comparable survival. The purpose of this study was to evaluate the Hangzhou criteria in a multi-center cohort.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| HCC | — | UNRESOLVED | — |
| Liver Transplantation | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (2)
- label
- Fulfilling Hangzhou criteria
- description
- Patients flfilling Hangzhou critieria: Without macrovascular invasion Tumor burden \<=8 cm Preoperative AFP level \<=400 ng/mL Histopathologic grades I, II
- label
- Exceeding Hangzhou criteria
- description
- Patients exceeding Hangzhou critieria
Primary outcomes (1)
- measure
- Overall survival
- timeFrame
- 5 years
- description
- Overall survival
Secondary outcomes (1)
- measure
- Recurrence rate
- timeFrame
- 5 years
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Aged ≥18 years and \<=75 with HCC confirmed by histopathology; * Undergoing a primary whole or split liver transplant from a deceased donor; Exclusion Criteria: * Incomplete follow-up; * Missing essential data for analysis (tumor size, number, differentiation grade, α-fetoprotein (AFP)) ; * Vascular invasion according to radiological criteria; * Perioperative mortality (\<30 days) ;
References
Publications (0)
Data not yet available
No reference posted for this study.