Clinical trial · Interventional
Impact of nrTMS Therapy on the Progress of Neurorehabilitation
Evaluation of the Benefit of Navigated Repetitive Transcranial Magnetic Stimulation for Therapy of Surgery-related Motor Deficits in Brain Tumor Patients
NCT03982329CI-TRIAL-00039018unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Low-frequency navigated repetitive transcranial magnetic stimulation (nrTMS) of the non-damaged hemisphere to increase cortical excitability of the damaged hemisphere and to reduce the increased neuronal inhibition in patients suffering from new surgery-related paresis after brain tumor resection
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Transcranial Magnetic Stimulation, Repetitive | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| navigated repetitive transcranial magnetic stimulation | Device | — | UNRESOLVED |
| physical therapy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- nrTMS group
- description
- 15 minutes low-frequency nrTMS (1 Hz) of the uneffected hemisphere at 7 consecutive days
- interventionNames
- Device: navigated repetitive transcranial magnetic stimulation
- Procedure: physical therapy
- type
- SHAM_COMPARATOR
- label
- sham group
- description
- 15 minutes sham stimulation of the uneffected hemisphere at 7 consecutive days
- interventionNames
- Procedure: physical therapy
Primary outcomes (1)
- measure
- Change of Fugl-Meyer Assessment (FMA)
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * New surgery-related paresis of upper extremity after brain tumor resection * Written informed consent for participation Exclusion Criteria: * Contraindications for MRI * Contraindications for nrTMS * Only biopsy instead of tumor resection * Patients without preserved MEP response as measured by postoperative nTMS motor mapping
References
Publications (1)
- DERIVEDIlle S, Kelm A, Schroeder A, Albers LE, Negwer C, Butenschoen VM, Sollmann N, Picht T, Vajkoczy P, Meyer B, Krieg SM. Navigated repetitive transcranial magnetic stimulation improves the outcome of postsurgical paresis in glioma patients - A randomized, double-blinded trial. Brain Stimul. 2021 Jul-Aug;14(4):780-787. doi: 10.1016/j.brs.2021.04.026. Epub 2021 May 11. PMID 33984536