Clinical trial · Interventional
Unusual Toxicity Induced by Radiotherapy
Collection of Biological Samples for Stydy of Unusual Toxicity Induced by Radiotherapy
NCT03980977CI-TRIAL-00071838CRYOTOXcompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In order to evaluate the physiopathological knowledge of the different pathological manifestations associated with individual radiosensitivity, it seems essential to carry out this pilot study. It has agglomerated homogeneous tissue samples to identify new biomarkers for patient diagnosis and follow-up, and may predict the therapeutic response. These knowledge will help to treatment customization.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| blood sample | Other | — | UNRESOLVED |
| skin biopsy | Other | — | UNRESOLVED |
| tumor biopsy | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- skin and/or tumor Biopsy and blood sample
- interventionNames
- Other: skin biopsy
- Other: tumor biopsy
- Other: blood sample
Primary outcomes (1)
- measure
- skin fibroblast radiosensitivity
- timeFrame
- 2 to 3 months after skin biopsy
- description
- The number of residual double strand break at 24 hours (number of 53BP1 foci) after a dose of 2 Gy will be quantified with indirect immunofluorescence
Secondary outcomes (1)
- measure
- tumor cells radiosensitivity
- timeFrame
- 2 to 3 months after tumor biopsy
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 2 Years
Show eligibility criteria text
Inclusion Criteria: * Child or teenager aged 2 to \<18 * Man, Woman\> 18 years old * Patient with one of these situations: * Unusual toxicity in progress or after radiotherapy * Indication of radiotherapy and suspicion of abnormal pathways of response to ionizing radiation - constitutional (genetic disease) or acquired (systemic disease) - which may generate unusual radioinduced toxicity * Patient information and informed consent signed by the patient. For children and teenager : information to parents and obtaining informed consent * Affiliation to a social security scheme. Exclusion Criteria: * Contraindication for skin and / or tumoral biopsy * Contraindication for blood sample of 2.5 ml * Persons deprived of liberty or under supervision
References
Publications (0)
Data not yet available
No reference posted for this study.