A Study of Azacitidine for Patients With Int/High -Risk MDS and AML-MRC

Inclusion Criteria:

1. Aged between 18-75 years old, male or female;
2. Int/high risk MDS AND AML patients (non-AML-M3) diagnosed according to the 2008 World Health Organization (WHO) diagnosis of myeloid malignant disease;
3. The ECOG behavior status score is 0-3 points;
4. The expected survival time is ≥ 3 months;
5. Ability to understand and be willing to sign the informed consent form of this trial.

Exclusion Criteria:

1. In the past, allergy to the drug contained in the test protocol or to a drug similar to the chemical structure of the test drug;
2. There are serious active infections;
3. Patients with clinically significant QTc interval prolongation (male \> 450ms, female \> 470ms), ventricular tachycardia (VT), atrial fibrillation (AF), grade II or higher heart block, myocardial infarction (MI) Patients with coronary heart disease who have congestive heart failure (CHF) within 1 year and who are symptomatic for medical treatment;
4. Heart B-ultrasound shows patients with end-diastolic pericardial cavity dark area width ≥ 10mm;
5. Patients with active bleeding;
6. Patients with new diseases such as thrombosis, embolism and cerebral hemorrhage in the past six months;
7. Abnormal liver function (total bilirubin \> 1.5 times the upper limit of normal value, 2.5 times the upper limit of ALT / AST \> normal value or 5 times the upper limit of ALT / AST \> normal value in patients with liver invasion), abnormal renal function (serum Creatinine \> 1.5 times the upper limit of normal);
8. The investigator determined that it was not suitable for the participants.