Clinical trial · Interventional
Resting-State Functional MRI in Glioma Patients Before and After Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This clinical trial studies how well resting-state functional magnetic resonance imaging (MRI) and cerebrovascular reactivity (CVR) MRI performed before and after surgery works in measuring the effects on language in patients with glioma. Mapping language function before brain tumor resection is crucial for preventing post-surgical deficits and maximizing restoration of language function following surgery. Additional imaging, such as resting-state functional MRI and CVR MRI, may help measure the language network in the brain before surgery and any effects on language function after surgery.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Mass | — | UNRESOLVED | — |
| Glioma | Glioma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Functional Magnetic Resonance Imaging | Procedure | — | UNRESOLVED |
| Magnetic Resonance Imaging | Procedure | — | UNRESOLVED |
| Resting State Functional Connectivity Magnetic Resonance Imaging | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Diagnostic (fMRI, CVR MRI, rs-fMRI)
- description
- Patients undergo standard of care fMRI, CVR MRI over 3 minutes, and rs-fMRI over 6 minutes 1 month before and within 6 weeks after standard of care surgery.
- interventionNames
- Procedure: Functional Magnetic Resonance Imaging
- Procedure: Magnetic Resonance Imaging
- Procedure: Resting State Functional Connectivity Magnetic Resonance Imaging
Primary outcomes (1)
- measure
- Detectability of language networks
- timeFrame
- Up to 6 weeks
- description
- Will be performed using resting-state-functional magnetic resonance imaging (rs-fMRI). The receiver operating characteristic (ROC) analysis will be carried out to compare the difference between the diagnostic performance of the proposed method and that of the data-driven rs-fMRI method. The study will evaluate the performance of rs-fMRI by comparing with the standard of care intraoperative direct cortical stimulation.
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with newly diagnosed brain mass suspected to be gliomas * English speaker * Right handed * Tumor is located on or adjacent to Broca's or Wernicke's areas in the hemisphere suspected to be dominant for language * No prior history of neurologic disease or insult, or neuropsychiatric illness requiring treatment that would affect cognition in the opinion of the attending neuropsychologist * Patients who will undergo neurosurgical resection * Patients who are on neurosurgical evaluation will undergo direct cortical stimulation (DCS) as standard of care * Patients who will complete pre- and postoperative neuropsychological testing per standard of care * Pregnant women Exclusion Criteria: * Patients with prior radiation or chemotherapy * Patients cannot give informed consent * Patients cannot undergo MRI and functional MRI examinations
References
Publications (0)
Data not yet available