Clinical trial · Observational
Molecular Basis of Pediatric Liver Cancer
Genetic and Molecular Basis of Pediatric Liver Cancer
NCT03959800CI-TRIAL-00121248recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this retrospective and prospective project is to understand the molecular and genetic basis of liver cancer of childhood. Understanding the molecular and genetic bases of liver cancers can offer a better classification based on tumor biology, mechanisms and predisposition.
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Childhood Liver Cancer | Childhood Malignant Liver Neoplasm | ALIAS | 0.90 |
| Embryonal Sarcoma of Liver (Disorder) | — | UNRESOLVED | — |
| Hepatoblastoma | Hepatoblastoma | ONTOLOGY_EXACT | 0.98 |
| Hepatocellular Carcinoma | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Liver Malignant Tumors | — | UNRESOLVED | — |
| Rhabdoid Tumor of Liver | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (5)
- measure
- Gene sequencing
- timeFrame
- Recurrence free survival at 2 years
- description
- DNA sequence variants
- measure
- Gene expression analysis
- timeFrame
- Recurrence free survival at 2 years
- description
- Differentially expressed genes
- measure
- Status of genome-wide chromatin accessibility
- timeFrame
- Duration of active chemotherapy to two years after surgical treatment
- description
- chromatin accessibility
- measure
- Epigenetic change
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 0 Years
- Maximum age
- 99 Years
Show eligibility criteria text
Inclusion Criteria: * Prior or current treatment for a childhood liver tumor, malignant or benign, at age \<21 years. * Biological parents and siblings of eligible children. Exclusion Criteria: * No prior or current treatment for a childhood liver tumor. * Non-biological parents, legal guardians, or non-biological siblings of eligible children.
References
Publications (0)
Data not yet available
No reference posted for this study.