Clinical trial · Interventional
Ultrasound for the Detection of Oxaliplatin-Induced Peripheral Neuropathy
A Pilot Study Using Ultrasound for the Detection of Oxaliplatin-Induced Peripheral Neuropathy
NCT03958747CI-TRIAL-00118767completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This pilot clinical trial studies how well ultrasound works in detecting oxaliplatin-induced neuropathy in participants with gastrointestinal cancer. Ultrasound may work better in diagnosing and detecting neuropathy in gastrointestinal cancer participants treated with the chemotherapy drug called oxaliplatin.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Gastrointestinal Cancer | Malignant Digestive System Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (6)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Abbreviated Neurologic Exam | Other | — | UNRESOLVED |
| Blood draw | Other | — | UNRESOLVED |
| Nerve Conduction Study | Diagnostic Test | — | UNRESOLVED |
| QLQ-CIPN20 Questionnaire Administration | Other | — | UNRESOLVED |
| Skin Biopsy | Procedure | — | UNRESOLVED |
| Ultrasound - Serial and Tibial Nerve | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Ultrasound
- description
- Undergo peripheral nerve ultrasound
- interventionNames
- Diagnostic Test: Ultrasound - Serial and Tibial Nerve
- Procedure: Skin Biopsy
- Other: Abbreviated Neurologic Exam
- Other: Blood draw
- Diagnostic Test: Nerve Conduction Study
- Other: QLQ-CIPN20 Questionnaire Administration
Primary outcomes (1)
- measure
- Tibial Nerve Cross-Sectional Area Comparison
- timeFrame
- Up to 30 days
- description
- Tibial nerve cross-sectional area determined by ultrasound in oxaliplatin-induced peripheral neuropathy patients will be transformed to compare to historical data previously collected from healthy adults and oxaliplatin-induced peripheral neuropathy patients using analysis of variance (ANOVA).
Secondary outcomes (9)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Any gastrointestinal cancer including colon, rectal, colorectal, pancreas, esophageal, or other (any stage) * Previously or currently receiving oxaliplatin -based chemotherapy. * Clinical symptoms of peripheral neuropathy noted in medical record and suspected to be secondary to oxaliplatin -based therapy. * Ability and willingness to understand and sign an informed consent. Exclusion Criteria: * Self-reported or documented history of pre-existing peripheral neuropathy prior to initiation of oxaliplatin chemotherapy. * Unable to provide history.
References
Publications (0)
Data not yet available
No reference posted for this study.