Clinical trial · Interventional
HeartPhone Cancer Survivors Trial 2019
Digital Intervention to Promote Physical Activity and Improve Cardiovascular Health Among Cancer Survivors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Futility in recruitment
Summary
Brief summary (as posted)
This is a behavioral study that will examine changes in physical activity and vascular health in response to a digital tool (app) that will appear on participant's lock screen of their Android phone. Participants will be asked to use this app for 3 months and to wear a Fitbit device continuously throughout the study. Participants will be asked to complete questionnaires, participate in fitness testing and measures of cardiovascular health at 3 months and 6 months after baseline assessments. The hypothesis is that exposure to the app will lead to increased physical activity volume and improved microvessel function.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Leukemia | Leukemia | ONTOLOGY_EXACT | 0.90 |
| Lymphoma | Lymphoma | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Acetylcholine | Drug | — | UNRESOLVED |
| HeartPhone app | Behavioral | — | UNRESOLVED |
| L-Arginine, N2-((4-Methylphenyl)Sulfonyl)-, Methyl Ester | Drug | — | UNRESOLVED |
| Sodium Nitroprusside | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- HeartPhone Intervention
- description
- Participants install the HeartPhone app on their smartphone. This app presents an image on a splash screen every time they activate their device. The image is randomly drawn from an image bank in the app. Repeated exposure to the image is designed to condition a more favorable automatic affective evaluation of physical activity and lead to increased physical activity.
- interventionNames
- Behavioral: HeartPhone app
- Drug: Acetylcholine
- Drug: Sodium Nitroprusside
- Drug: L-Arginine, N2-((4-Methylphenyl)Sulfonyl)-, Methyl Ester
Primary outcomes (2)
- measure
- Installation of the Heartphone Application.
- timeFrame
- 3 months
- description
- Change in the total physical activity volume from baseline to 3 months as measured by the Actigraph GT3XP-BTLE (total activity counts)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Age 18-65 years * Diagnosis of breast cancer, leukemia, or lymphoma \<15 yrs * Completed chemotherapy with cardiotoxic anthracycline-based agents 1+ year ago * English-proficiency * Own \& use smartphone with Android operating system Main Study and Ancillary Study Exclusion Criteria: * Currently receiving curative treatment for cancer * 90+ min/week moderate (or greater) intensity PA * Any medical contraindications on the Physical Activity Readiness Questionnaire * Require an assistive device for mobility or has any other condition that may limit or prevent participation in moderate-intensity physical activity * Current smoker * Pregnant or planning to become pregnant in the next 6 mos/breastfeeding * Allergy to test substances * Allergy to latex Ancillary Study: * Taking metformin * Current medications that could conceivably alter the cardiovascular or thermoregulatory control or responses (e.g. beta blockers, calcium channel blockers, angiotensin receptor blockers)
References
Publications (0)
Data not yet available