Physical Activity for Myeloma Autograft Longitudinal Study

Physical exercises program is known to improve quality of life, chronical fatigue and appears to be a behavioural recommendation against cancer as primary and tertiary prevention. Nutritional status is also important in cancer patients: a loss of 5% of weight increases the complication risks and decreases survival and the quality of life. Interactions between physical activity and haematological malignancies are less described compared to solid cancers. Methodology and protocols are also heterogeneous. Supervised exercises program improves the physical condition and the quality of life; however there are few randomised studies versus a controlled group. Post autograft evaluation for myeloma patients showed a physical deficit with increased fat mass, but in this particular population physical exercises need to be more explored. This project is a randomised study versus controlled group that evaluates supervised physical exercises program in a homogenous population: patients under-65-years-old with multiple myeloma and who will undergo autologous stem cell transplantation.

Sex

All

Minimum age

18 Years

Maximum age

65 Years

Inclusion Criteria:

* Under 65-year-old patient
* more than 18 years old
* Hospitalized for autologous stem cell transplantation
* First or second line therapy for multiple myeloma
* Chemotherapy regimen with melphalan
* Patient affiliated to the social security system
* Signed informed consent form
* Patient who have computer and internet connection at home

Exclusion Criteria:

* Over-65-year-old patient
* Other haematological malignancies
* More than 2 treatment lines
* Other regimen of chemotherapy for autograft than melphalan
* Contraindication to physical exercises: uncontrolled arterial hypertension or diabetes, heart or respiratory failure, psycho-cognitive disorders that may compromise the physical exercises program
* dialyzed patient
* Adult patient under tutelage