Clinical trial · Observational
PEDIATRIC SONICS: Pediatric Study of Neuropsychology and Imaging in CNS Demyelinating Syndromes.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Central Nervous System (CNS) demyelinating conditions include multiple sclerosis (MS), Acute Disseminated Encephalomyelitis (ADEM), Neuromyelitis Optica Spectrum Disorder (NMOSD), Optic Neuritis (ON) and Transverse Myelitis (TM). The symptoms of these conditions are quite variable from patient to patient, but can include motor, sensory, visual, gait and cognitive changes. Conventional MRI can be used to look for new anatomic changes, but fails to measure underlying biochemical changes in brain tissue. The purposes of this study are to identify the biologic and anatomic correlations between cognitive profiles and disease activity using MRI imaging techniques.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Acute Disseminated Encephalomyelitis | — | UNRESOLVED | — |
| Multiple Sclerosis, Relapsing-Remitting | — | UNRESOLVED | — |
| Neuromyelitis Optica | — | UNRESOLVED | — |
| Transverse Myelitis | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- CNS demyelinating diagnosis
- description
- Diagnosis of CNS demyelinating disorder: Multiple Sclerosis, Transverse Myelitis, Neuromyelitis Optica, Acute Disseminated Encephalomyelitis, anti-MOG antibody, Optic Neuritis. * 3T and 7T MRI * Neuropsychological testing * Optical Coherence Tomography * Questionnaires: Quality of Life and Behavior scales * Non invasive clinical assessment : Walking, hand and eye coordination tests Repeat same research activities one to year and a half year later
- label
- Healthy Control
- description
- * 3T and 7T MRI * Neuropsychological testing * Optical Coherence Tomography * Questionnaires: Quality of Life and Behavior scales * Non invasive clinical assessment : Walking, hand and eye coordination tests Repeat same research activities one year to a year and a half later
Primary outcomes (20)
- measure
- MRI Brain without contrast
- timeFrame
- 10-14 months
- description
- 3T MRI
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 12 Years
- Maximum age
- 21 Years
Show eligibility criteria text
Inclusion Criteria: 1. Diagnosis of Multiple Sclerosis , ADEM, anti-MOG antibody associated CNS demyelination 2. Age 12 to 21 inclusive at time of enrollment 3. Ability of parent or legal guardian to provide informed consent if participant is under 18. 4. Ability of patients age 12-17 to give assent 5. Completion of the signed HIPPA authorization form by a parent or legal guardian or by participants (18 years of age). Exclusion Criteria: 1. Known history of traumatic brain injury that required medical care 2. Non-English speaking (based on standardized neuropsychological testing and questionnaires) 3. Claustrophobic, the presence of metallic braces, implants or medical devices that are unsafe at 3T or 7T and/or interfere with the MRI/MRS signals
References
Publications (0)
Data not yet available