Clinical trial · Observational
Spontaneous Coronary Artery Dissection (SCAD) and Autoimmunity
Determining the Association Between Spontaneous Coronary Artery Dissection (SCAD) and Autoimmunity
NCT03941184CI-TRIAL-00048432completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This case control study aims to determine whether spontaneous coronary artery dissection (SCAD) is associated with autoimmune diseases and to update the incidence of SCAD in a population-based cohort.
Conditions
Conditions (29)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Addison Disease | — | UNRESOLVED | — |
| Ankylosing Spondylitis | — | UNRESOLVED | — |
| Antiphospholipid Antibody Syndrome | — | UNRESOLVED | — |
| Celiac Disease | — | UNRESOLVED | — |
| Crohn Disease | — | UNRESOLVED | — |
| Dermatomyositis | — | UNRESOLVED | — |
| Graves Disease | — | UNRESOLVED | — |
| Guillain-Barre Syndrome | — | UNRESOLVED | — |
| Hashimoto Thyroiditis | — | UNRESOLVED | — |
| Hepatitis, Autoimmune | — | UNRESOLVED | — |
| Multiple Sclerosis | — | UNRESOLVED |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (2)
- label
- SCAD cases
- description
- SCAD cases will be identified based on presence of at least one diagnosis code for SCAD followed by manual verification by a trained individual, OR, inclusion in the previously validated SCAD cohort (Tweet 2012).
- label
- Controls without SCAD
- description
- Potential controls will be identified based on absence of any SCAD diagnosis codes.
Primary outcomes (2)
- measure
- Odds of autoimmune disease in SCAD cases compared to controls
- timeFrame
- Through study completion, or approximately 50 years (average age of study participants)
- measure
- Incidence Rate of SCAD
- timeFrame
- Through study completion, or approximately 50 years (average age of study participants)
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 110 Years
Show eligibility criteria text
Inclusion Criteria: * Adults age 18 to 110 * Residence in Olmsted County. Note: if sufficient numbers cannot be reached using only Olmsted County, will expand to the 27-county region. Exclusion Criteria: * None
References
Publications (9)
- BACKGROUNDTweet MS, Hayes SN, Pitta SR, Simari RD, Lerman A, Lennon RJ, Gersh BJ, Khambatta S, Best PJ, Rihal CS, Gulati R. Clinical features, management, and prognosis of spontaneous coronary artery dissection. Circulation. 2012 Jul 31;126(5):579-88. doi: 10.1161/CIRCULATIONAHA.112.105718. Epub 2012 Jul 16. PMID 22800851
- BACKGROUNDMcGonagle D, McDermott MF. A proposed classification of the immunological diseases. PLoS Med. 2006 Aug;3(8):e297. doi: 10.1371/journal.pmed.0030297. PMID 16942393
- BACKGROUNDSt Sauver JL, Grossardt BR, Yawn BP, Melton LJ 3rd, Pankratz JJ, Brue SM, Rocca WA. Data resource profile: the Rochester Epidemiology Project (REP) medical records-linkage system. Int J Epidemiol. 2012 Dec;41(6):1614-24. doi: 10.1093/ije/dys195. Epub 2012 Nov 18. PMID 23159830
- BACKGROUNDTweet MS, Kok SN, Hayes SN. Spontaneous coronary artery dissection in women: What is known and what is yet to be understood. Clin Cardiol. 2018 Feb;41(2):203-210. doi: 10.1002/clc.22909. Epub 2018 Mar 1. PMID 29493808
- BACKGROUNDHayes SN, Kim ESH, Saw J, Adlam D, Arslanian-Engoren C, Economy KE, Ganesh SK, Gulati R, Lindsay ME, Mieres JH, Naderi S, Shah S, Thaler DE, Tweet MS, Wood MJ; American Heart Association Council on Peripheral Vascular Disease; Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Genomic and Precision Medicine; and Stroke Council. Spontaneous Coronary Artery Dissection: Current State of the Science: A Scientific Statement From the American Heart Association. Circulation. 2018 May 8;137(19):e523-e557. doi: 10.1161/CIR.0000000000000564. Epub 2018 Feb 22. PMID 29472380
- BACKGROUNDAdlam D, Alfonso F, Maas A, Vrints C; Writing Committee. European Society of Cardiology, acute cardiovascular care association, SCAD study group: a position paper on spontaneous coronary artery dissection. Eur Heart J. 2018 Sep 21;39(36):3353-3368. doi: 10.1093/eurheartj/ehy080. No abstract available.