Clinical trial · Interventional
The Effect of Deep Neuromuscular Block on the Perioperative Stress Response Reduction and Postoperative Recovery Enhancement in Robot-assisted Stomach Cancer Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Stress reactions caused by surgical stimuli can cause sympathetic nervous system activation and increased stress hormones, such as catecholamines, inflammatory cytokines, and pituitary hormones, and insulin resistance. In addition, increased catecholamine levels may exacerbate postoperative outcomes, especially delayed wound recovery, increased cardiovascular and respiratory complications, and immunosuppression. In particular, it is important to reduce the stress response for cancer patients during surgery because they are already immunocompromised status and more vulnerable to perioperative stressful situation. However, there are insufficient results on the benefits of deep neuromuscular block in these patients, although some have reported a reduction of postoperative pain and fewer complications in the deep neuromuscular block compared with moderate neuromuscular block. Therefore, the investigators aim to investigate the difference in the stress response of patients who received conventional moderate neuromuscular block or deep neuromuscular block in robot-assisted gastric cancer surgery.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Stomach Cancer | Malignant Gastric Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Deep neuromuscular block with 'rocunium®' | Drug | — | UNRESOLVED |
| Moderate neuromuscular block with 'rocunium®' | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Deep neuromuscular block group
- interventionNames
- Drug: Deep neuromuscular block with 'rocunium®'
- type
- EXPERIMENTAL
- label
- Moderate neuromuscular block group
- interventionNames
- Drug: Moderate neuromuscular block with 'rocunium®'
Primary outcomes (4)
- measure
- Difference of stress responses between deep block and moderate block
- timeFrame
- at baseline (T1)
- description
- Comparison of perioperative stress responses with biomarkers including cortisol, interleukin-6, natural killer cell and HRV between deep neuromuscular block group and moderate neuromuscular group
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * 1\. ASA Ⅰ - Ⅱ patients between 20 and 65 years undergoing robot-assisted gastric cancer surgery Exclusion Criteria: * 1\. Patients with neuromuscular disease * 2\. Hypertensive patients with β-blockers * 3\. Diabetic patients receiving insulin therapy * 4\. Patients with severe heart (EF \<45%), kidney (GFR \<60), liver dysfunction (ALT / AST\> 100) * 5\. Patients with obesity (BMI ≥30) * 6\. Do not understand Korean language * 7\. For vulnerable subjects who are unable to obtain consent
References
Publications (0)
Data not yet available