Clinical trial · Observational
Hamburg City Health Study - a German Cohort Study
A Single Center, Prospective, Epidemiologic Cohort Study With Emphasis on Imaging to Improve the Identification of Individuals at Risk for Major Chronic Diseases and to Improve Early Diagnosis and Survival
NCT03934957CI-TRIAL-00038418HCHSrecruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The Hamburg City Health Study (HCHS) is a large, prospective, long-term, population-based cohort study and a unique research platform and network to obtain substantial knowledge about several risk and prognostic factors in major chronic diseases.
Conditions
Conditions (10)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Coronary Heart Disease | — | UNRESOLVED | — |
| Dementia | — | UNRESOLVED | — |
| Health Care | — | UNRESOLVED | — |
| Obesity | — | UNRESOLVED | — |
| Ocular Diseases | — | UNRESOLVED | — |
| Periodontal Diseases | — | UNRESOLVED | — |
| Respiratory Disease | — | UNRESOLVED | — |
| Stroke | — | UNRESOLVED | — |
| Vascular Diseases | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- self-reported Information on changes in health in the participants
- timeFrame
- yearly up to 12 years
- description
- coronary artery disease atrial fibrillation heart failure dementia stroke cancer such as prostate cancer and skin cancer chronic kidney diseases migraine musculoskeletal diseases such as osteoporosis and bone metastasis ocular diseases such as glaucoma, macular degeneration, fundus hypertonicus, retinal vessel disease and neoplasm oral health including periodontal disease, oropharyngeal cancer and human papillomavirus (HPV)-infection psychiatric and psychosomatic disorders such as mental disorder or late - last depression pulmonary diseases such as obstructive lung disease sexual disorder skin diseases such as psoriasis, chronic wounds and inflammation vascular diseases such as aortic aneurysm, thrombosis and peripheral arterial disease
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 45 Years
- Maximum age
- 74 Years
Show eligibility criteria text
Inclusion Criteria: * Inhabitant of the city of Hamburg at the time of inclusion into the study (Inclusion is time of written consent) * Age 45 to 74 years * Personally signed informed consent Exclusion Criteria: * Insufficient knowledge of the German language, in order to understand study documents and computer assisted interview without translation * Physical or psychological incapability to travel to the study center and to cooperate in the investigations
References
Publications (15)
- DERIVEDRiedl KA, Reuter K, Bottcher A, Hullebrand M, Hennemuth A, Cavus E, Braren R, Kirchhof P, Blankenberg S, Betz CS, Lund G, Muellerleile K, Hoffmann AS. CMR-based aortic stiffness parameters in a symptomatic high risk obstructive sleep apnea cohort: results from the population-based Hamburg City Health Study. BMC Cardiovasc Disord. 2026 Aug 13;26(1):691. doi: 10.1186/s12872-026-06450-z. PMID 42587278
- DERIVEDKoch LR, Becker S, Bosnjak A, Biedermann M, Jadidi AS, Westermann D, Lehrmann H, Loewe A, Arentz T, Schell M, Thomalla G, Engler D, Schnabel RB, Eichenlaub M. Amplified P-wave duration predicts incident atrial fibrillation in the general population: Results from the Hamburg City Health Study. Heart Rhythm O2. 2026 Apr 2;7(7):1242-1249. doi: 10.1016/j.hroo.2026.03.033. eCollection 2026 Jul. PMID 42488147
- DERIVEDSchmidt-Lauber C, Ebinghaus M, Borof K, Lieske B, Klopp A, Thompson C, Wees L, Dawood Z, Heydecke G, Beikler T, Huber TB, Aarabi G. Association of periodontitis with reduced kidney function and albuminuria in early chronic kidney disease: a population-based study. Int J Oral Sci. 2026 Apr 6;18(1):33. doi: 10.1038/s41368-026-00435-6. PMID 41936582
- DERIVEDJessen B, Lowe B, Twerenbold R, Harter M, Harth V, Hoven H, Schmidt-Lauber C, Huber TB, Shedden-Mora M. Biopsychosocial Correlates of Somatic Symptom Burden in CKD: Results of the Hamburg City Health Study. Kidney360. 2026 May 1;7(5):1065-1075. doi: 10.34067/KID.0000001130. Epub 2026 Jan 30. PMID 41615722
- DERIVEDJensen M, Vettorazzi E, Weber P, Petersen M, Schell M, Nagele FL, Link MA, Schlemm E, Rimmele DL, Becher PM, Cheng B, Blankenberg S, Kirchhof P, Zeller T, Twerenbold R, Thomalla G. Association of Cardiac Biomarkers With Structural Brain Changes and Cognitive Impairment: Results From the Hamburg City Health Study. Neurology. 2025 Aug 12;105(3):e213865. doi: 10.1212/WNL.0000000000213865. Epub 2025 Jul 3. PMID 40609062
- DERIVEDRiccio C, Arnold N, Koliopanos G, Link V, Guo L, Betschart RO, Zeller T, Blankenberg S, Ziegler A, Twerenbold R. Familial Hypercholesterolemia: Prevalence and Discrepancy between Genotype and Phenotype. Findings of the Population-based Hamburg City Health Study. Dtsch Arztebl Int. 2025 Sep 19;122(19):511-516. doi: 10.3238/arztebl.m2025.0110.