Image Guided Surgery in Sinonasal Inverted Papilloma

Inclusion Criteria:

* Biopsy confirmed diagnosis of SNIP and scheduled to undergo surgical resection;
* Age ≥ 18 years;
* Written informed consent;
* Mentally competent person that is able and willing to comply with study procedures.

Exclusion Criteria:

* Medical or psychiatric conditions that compromise the patient's ability to give informed consent;
* Concurrent uncontrolled medical conditions;
* Received an investigational drug within 30 days prior to the dose of bevacizumab-IRDye800CW;
* Tumors at sites of which the surgeon would assess that in vivo imaging would not be feasible;
* History of myocardial infarction, cerebrovascular accident, uncontrolled cardiac heart failure, significant liver disease or unstable angina within 6 months prior to enrollment;
* Inadequately controlled hypertension with or without current antihypertensive medications;
* History of infusion reactions to bevacizumab or other monoclonal antibody therapies;
* Pregnant or lactating women. Documentation of a negative pregnancy test must be available for women of childbearing potential. Woman of childbearing potential are premenopausal women with intact reproductive organs and women less than two years after menopause;
* Lab values that in the opinion of the primary surgeon would prevent surgical resection;
* Life expectancy \< 12 weeks;